Summary
Lysozyme, a1-Antichymotrypsin and a1-Antitrypsin were demonstrated by an immunoperoxidase technique (PAP) in malignant cells of adenocarcinomas of the stomach but not of the large intestine. Lymph-node metastases showed identical immunoreactivity to that of the primary tumour. Neoplasms arising from the cardia, the body and the pyloric antrum of the stomach showed different immunostaining reactions: It seems that these differences partly reflect the distribution of lysozyme, a1-Antichymotrypsin and a1-Antitrypsin in the normal gastric mucosa. The usefulness of our findings in the identification of the primary tumour in cases of lymph node metastases of unknown origin, is also discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Geboes K, Ray MB, Rutgeerts P, Gallea F, Desmet VJ, Vantrappen G (1982) Morphological identification of alpha-1-antitrypsin in the human small intestine. Histopathology 6:55–60
Heitz PU, Wegmann W (1980) Identification of neoplastic Paneth cells in an adenocarcinoma of the stomach using lysozyme as a marker, and Electron Microscopy. Virchows Arch [Pathol Anat] 386:107–116
Junqueira LC, Carneiro J (1980) Basic Histology, 3rd edition, p. 307–334, Los Altos, California, Lange Medical Publications
Kittas C, Aroni K, Matani A, Papadimitriou CS (1982) Immunocytochemical demonstration of a1-Antitrypsin and a1-Antichymotrypsin in human gastrointestinal tract. Hepato-Gastroenterology, [in press]
Klockars M, Reitamo S (1975) Tissue distribution of lysozyme in man. J Histochem Cytochem 23:932–940
Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta pathol microbiol Scand 64:31
Mason DY, Taylor CR (1975) The distribution of muramidase (lysozyme) in human tissues. J Clin Pathol 28:124–132
Montero C, Erlandsen SL (1978) Immunocytochemical and histochemical studies on intestinal epithelial cells producing both lysozyme and mucosubstance. Anat Rec 190:127–142
Sandow MJ, Whitehead R (1979) Progress repotr: The Paneth cell. Gut 20:420–431
Shousha S (1979) Paneth cell-rich papillary adenocarcinoma and a mucoid adenocarcinoma occuring synchronously in colon: a light and electron microscopic study. Histopathology 3:489–501
Soga J, Tazawa K, Wada K, Tuto T (1971) Argentaffin cell adenocarcinoma of the stomach an atypical carcinoid? Cancer 28:999–1003
Sternberger LA, Hardy PH Jr, Cuculis JJ, Meyer HG (1970) The unlabeled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorse radish peroxidase) and its use in identification of spirochetes J Histochem Cytochem 18:315–333
Taylor CR (1974) The nature of Reed-Sternberg cells and other malignant “reticulum” cells. Lancet II 802–807
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kittas, C., Aroni, K., Kotsis, L. et al. Distribution of lysozyme, a1-Antichymotrypsin and a1-Antitrypsin in adenocarcinomas of the stomach and large intestine. Vichows Archiv A Pathol Anat 398, 139–147 (1982). https://doi.org/10.1007/BF00618865
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00618865