Virchows Archiv A

, Volume 398, Issue 2, pp 139–147 | Cite as

Distribution of lysozyme, a1-Antichymotrypsin and a1-Antitrypsin in adenocarcinomas of the stomach and large intestine

An immunohistochemical study
  • Christos Kittas
  • Kyriaki Aroni
  • Leonidas Kotsis
  • Constantinos S. Papadimitriou


Lysozyme, a1-Antichymotrypsin and a1-Antitrypsin were demonstrated by an immunoperoxidase technique (PAP) in malignant cells of adenocarcinomas of the stomach but not of the large intestine. Lymph-node metastases showed identical immunoreactivity to that of the primary tumour. Neoplasms arising from the cardia, the body and the pyloric antrum of the stomach showed different immunostaining reactions: It seems that these differences partly reflect the distribution of lysozyme, a1-Antichymotrypsin and a1-Antitrypsin in the normal gastric mucosa. The usefulness of our findings in the identification of the primary tumour in cases of lymph node metastases of unknown origin, is also discussed.

Key words

Gastrointestinal tumours Lysozyme a1-Antichymotrypsin a1-Antitrypsin 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Christos Kittas
    • 1
  • Kyriaki Aroni
    • 1
  • Leonidas Kotsis
    • 1
  • Constantinos S. Papadimitriou
    • 2
  1. 1.Department of Pathological AnatomyMedical School, University of AthensGoudi
  2. 2.Department of Pathological AnatomySchool of Medicine, University of IoanninaGreece

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