European Journal of Clinical Pharmacology

, Volume 15, Issue 4, pp 229–233 | Cite as

Exercise responses of healthy subjects in the evaluation of cardioselectivity ofβ-blockers

  • K. L. Woods
  • S. P. Linton
  • M. J. Kendall
  • E. B. Faragher
  • R. J. Grieve


The effects of intravenous propranolol, metoprolol, acebutolol and placebo on exercise-induced changes in heart rate and peak flow rate (PFR) have been studied in a group of healthy subjects. The three β-blockers produced significant and comparable reductions in exercise-induced tachycardia and the magnitude of the reduction was related to the log plasma concentration of each drug. Significant cardiac β-blockade was detectable for three hours after giving propranolol and for four hours after metoprolol and acebutolol. The exercise-induced changes in PFR were small and variable and were not significantly affected by any of the drugs. We conclude that, contrary to published reports, exercise-induced changes in heart rate and PFR in healthy subjects do not provide a satisfactory test system for assessing the selectivity of β-blockers.

Key words

propranolol metoprolol acebutolol exercise testing healthy subjects 


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • K. L. Woods
    • 1
  • S. P. Linton
    • 2
  • M. J. Kendall
    • 1
  • E. B. Faragher
    • 3
  • R. J. Grieve
    • 4
  1. 1.Department of Therapeutics and Clinical PharmacologyUniversity of BirminghamUnited Kingdom
  2. 2.Selly Oak HospitalBirminghamUnited Kingdom
  3. 3.Mathematical Analysis SectionGeigy PharmaceuticalsMacclesfieldUnited Kingdom
  4. 4.Department of MedicineUniversity of BirminghamUnited Kingdom

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