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European Journal of Clinical Pharmacology

, Volume 20, Issue 5, pp 371–374 | Cite as

Disposition of Cefoxitin in patients with ascites

  • M. J. Garcia
  • A. Dominguez-Gil
  • F. Diaz Perez
  • F. Perez Rodriguez
  • F. Dominguez Moronta
Originals

Summary

The pharmacokinetics of Cefoxitin was studied in 8 cirrhotic patients with ascites after i.v. administration of a single 30 mg/kg dose. Concentrations of cefoxitin in serum and in ascitic fluid were determined simultaneously by a microbiologic plate diffusion method. The antibiotic followed a two-compartment open kinetic model. In ascitic fluid, Cefoxitin reached its maximum concentration of 32.80±13,78 µg/ml 2 h after administration. The mean elimination constant from ascitic fluid was 0.201±0.008 h−1, significantly lower (p<0.05) than the slow disposition phase constant (β=0.556±0.17 h−1). At the dose studied and with a dosage interval of 8 h, the level of antibiotic in the ascitic fluid would be maintained at a value greater than the MIC of most cefoxitin-sensitive organisms.

Key words

cefoxitin cirrhosis pharmacokinetics ascites ascitic fluid level 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • M. J. Garcia
    • 1
  • A. Dominguez-Gil
    • 1
  • F. Diaz Perez
    • 2
  • F. Perez Rodriguez
    • 2
  • F. Dominguez Moronta
    • 2
  1. 1.Practical Pharmacy Department, Faculty of PharmacyUniversity of SalamancaSpain
  2. 2.Medical Pathology Department, Clinical HospitalUniversity of SalamancaSpain

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