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European Journal of Clinical Pharmacology

, Volume 34, Issue 6, pp 535–538 | Cite as

Meta-analysis of clinical trials: Summary of an international conference

  • J. P. Boissel
  • H. S. Sacks
  • A. Leizorovicz
  • J. Blanchard
  • E. Panak
  • J. C. Peyrieux
Special Articles

Summary

An international conference of clinicians, clinical investigators and biostatisticians discussed meta-analysis in relation to clinical trials, i.e. the combination of data from separate studies for the purpose of obtaining information that cannot be derived from the individual studies.

Meta-analysis can be a helpful tool for generating hypotheses for future trials, for studying the consistency of trials of the same or similar goals, and for generating more precise estimates of effect. There are still a number of unresolved questions about the methodology and interpretation of meta-analysis. Better and more uniform reporting of primary studies would increase the usefulness of meta-analysis.

Key words

meta-analysis clinical trials methodology biostatistics 

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References

  1. 1.
    Dickersin K, Hewitt P, Mutch L, Chalmers I, Chalmers TC (1985) Comparison of medline searching with a perinatal clinical trials database. Controlled Clin Trials 6: 306–317Google Scholar
  2. 2.
    Chan SS, Sacks HS, Chalmers TC (1982) The epidemiology of unpublished randomized control trials. Clin Res 30: 234A (abstract)Google Scholar
  3. 3.
    Rosenthal R (1979) The “File Drawer Problem” and tolerance for null results. Psychol Bull 86: 638–641Google Scholar
  4. 4.
    Sacks HS, Chalmers TC (1985) Meta-analysis of randomized control trials. Clin Res 33: 525A (abstract)Google Scholar
  5. 5.
    Chalmers TC, Smith H Jr, Blackburn B (1981) A method for assessing the quality of a randomized control trial. Controlled Clin Trials 2: 31–49Google Scholar
  6. 6.
    DerSimonian R, Charette L, McPeek B, Mosteller F (1982) Reporting on methodology in clinical trials. N Engl J Med 306: 1332–1337Google Scholar
  7. 7.
    Hedges LV, Olkin I (1985) Statistical methods for meta-analysis. Academic Press, FloridaGoogle Scholar
  8. 8.
    Rosenthal R (1984) Meta-analytic procedures for social research. Sage Publications, Beverly Hills, CAGoogle Scholar
  9. 9.
    Glass GV, McGaw B, Smith ML (1984) Meta-analysis in social research. Sage Publications, Beverly Hills, CAGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • J. P. Boissel
    • 1
  • H. S. Sacks
    • 2
  • A. Leizorovicz
    • 1
  • J. Blanchard
    • 3
  • E. Panak
    • 1
  • J. C. Peyrieux
    • 1
  1. 1.Unite de Pharmacologie CliniqueHôpital Neuro-CardiologiqueLyonFrance
  2. 2.Mount Sinai Medical CenterNew YorkUSA
  3. 3.Sanofi RechercheParisFrance

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