Journal of Comparative Physiology A

, Volume 157, Issue 4, pp 477–482 | Cite as

Taste response to 2,5-anhydro-d-hexitols; rigid stereospecificity of the furanose site in the sugar receptor of the flesh fly

  • Ichiro Shimada
  • Hiroyuki Horiki
  • Hiroshi Ohrui
  • Hiroshi Meguro
Article

Summary

2,5-Anhydro-d-mannitol with a fixed furanose ring stimulated the sugar receptor of the flesh fly (Fig. 1) and reacted with the furanose site (Fig. 3). This is the first direct evidence that a furanose can stimulate the sugar receptor and supports strongly the assumption thatβ-d-fructofuranose is the only stimulatory component in the solution ofd-fructose.

Rigid stereospecificity of the furanose site in the sugar receptor is discussed according to the effectiveness of various synthetic 2,5-anhydro-d-hexitols and related compounds (Table 2, Fig. 6).

At least four receptor sites are concluded to be in a single sugar receptor: a pyranose (P) site, a furanose (F) site, an aliphatic carboxylate (R) site and an aromatic amino acid (Ar) site.

Keywords

Sugar Carboxylate Direct Evidence Related Compound Aromatic Amino Acid 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Ichiro Shimada
    • 1
  • Hiroyuki Horiki
    • 2
  • Hiroshi Ohrui
    • 2
  • Hiroshi Meguro
    • 2
  1. 1.Department of Biological ScienceTohoku UniversitySendaiJapan
  2. 2.Department of Food Chemistry, Faculty of AgricultureTohoku UniversitySendaiJapan

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