Journal of Comparative Physiology A

, Volume 157, Issue 4, pp 477–482 | Cite as

Taste response to 2,5-anhydro-d-hexitols; rigid stereospecificity of the furanose site in the sugar receptor of the flesh fly

  • Ichiro Shimada
  • Hiroyuki Horiki
  • Hiroshi Ohrui
  • Hiroshi Meguro


2,5-Anhydro-d-mannitol with a fixed furanose ring stimulated the sugar receptor of the flesh fly (Fig. 1) and reacted with the furanose site (Fig. 3). This is the first direct evidence that a furanose can stimulate the sugar receptor and supports strongly the assumption thatβ-d-fructofuranose is the only stimulatory component in the solution ofd-fructose.

Rigid stereospecificity of the furanose site in the sugar receptor is discussed according to the effectiveness of various synthetic 2,5-anhydro-d-hexitols and related compounds (Table 2, Fig. 6).

At least four receptor sites are concluded to be in a single sugar receptor: a pyranose (P) site, a furanose (F) site, an aliphatic carboxylate (R) site and an aromatic amino acid (Ar) site.


Sugar Carboxylate Direct Evidence Related Compound Aromatic Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Ichiro Shimada
    • 1
  • Hiroyuki Horiki
    • 2
  • Hiroshi Ohrui
    • 2
  • Hiroshi Meguro
    • 2
  1. 1.Department of Biological ScienceTohoku UniversitySendaiJapan
  2. 2.Department of Food Chemistry, Faculty of AgricultureTohoku UniversitySendaiJapan

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