European Journal of Clinical Pharmacology

, Volume 34, Issue 2, pp 217–219 | Cite as

Effect of ascariasis and its treatment on drug absorption

  • N. A. Kshirsagar
  • M. V. Joshi
  • M. R. Takle
  • V. N. Acharya
  • R. S. Satoskar
Letter To The Editors


Ascariasis has been reported to impair the absorption of nutrients, vitamin A, and D-xylose, which is corrected on treatment. The effect of ascariasis and its treatment on the absorption of sulphadimidine and isoniazid has been investigated. There was no difference between drug absorption before and after the treatment or in comparison with a normal population.

Key words

ascaris isoniazid sulphadimidine drug absorption 


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  1. 1.
    Control of ascariasis (1964) WHO Technical Report Series 277: 1–46Google Scholar
  2. 2.
    Tripathi K, Gonzales F, Lottero H, Bolanos D (1971) Effect of ascaris infection on human nutrition. Am J Trop Med Hyg 20: 212–218Google Scholar
  3. 3.
    Mahalanabis O, Jalan KN, Maitra JK, Agarwal SK (1976) Vit A absorption in ascariasis. Am J Clin Nutr 29: 1372–1375Google Scholar
  4. 4.
    Craig CF, Faust EC (1943) Clinical parasitology. Lea and Febiger, Philadelphia, p 658Google Scholar
  5. 5.
    Varley H, Gowenlock AH, Beli M (1981) Practical clinical biochemistry, vol. 2, 5th edn. William Heinemann, London, p 347Google Scholar
  6. 6.
    Rao KVN, Kailasasam S, Menon NK, Radhakrishna S (1971) Inactivation of isoniazid by condensation in a syrup preparation. Bul WHO 45: 625–632Google Scholar
  7. 7.
    Ellard GA, Gammon PT, Wallace SM (1972) The determination of isoniazid and its metabolites in serum and urine. Biochem J 126: 449–458Google Scholar
  8. 8.
    Webster LT (1985) Drugs used in chemotherapy of helminthiasis. In: Goodman Gilman A, Goodman LS, Ral TN, Murad F (eds) Pharmacological basis of therapeutics. 7th edn. MacMillan, New York, p 347Google Scholar
  9. 9.
    Owen RL, Brandborg LL (1983) Parasitic disease. In: Gastrointestinal disease — Pathophysiology, diagnosis and management. Sleisenger MH, Fordtram JS (eds) WB Saunders, Philadelphia, pp 989–1022Google Scholar
  10. 10.
    Sivkumar B, Reddy V (1975) Absorption of vitamin A in children with ascariasis. Am J Trop Med Hyg 78: 114–118Google Scholar
  11. 11.
    Tripathi K, Duque E, Bolanos O, Lottero H, Mayoral DG (1972) Malabsorption syndrome in ascariasis. Am J Clin Nutr 25: 1276–1281Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • N. A. Kshirsagar
    • 1
  • M. V. Joshi
    • 1
  • M. R. Takle
    • 1
  • V. N. Acharya
    • 2
  • R. S. Satoskar
    • 1
  1. 1.Department of PharmacologySeth G. S. Medical College and K. E. M. HospitalParelIndia
  2. 2.Department of MedicineSeth G. S. Medical College and K. E. M. HospitalParelIndia

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