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European Journal of Clinical Pharmacology

, Volume 7, Issue 1, pp 59–60 | Cite as

Lack of effect of the appetite stimulant pizotifen (BC 105) on the absorption of isonicotinylhydrazine

  • E. E. Ohnhaus
  • E. Nüesch
Originals

Summary

Pizotifen (BC 105) has an orexigenic effect in patients with pulmonary tuberculosis. As these cases are often treated with isonicotinylhydrazine (INH), any effect of one of these drugs on the absorption of the other has been examined in a cross-over study in 8 healthy male volunteers. No difference was found between the absorption of INH given alone or together with pizotifen. It should be safe, therefore, to employ the combination of the orexigenic drug and INH in the treatment of tuberculosis as there will be no change in the concentration of therapeutic drug achieved.

Key words

Pizotifen isonicotinylhydrazine orexigen tuberculosis pharmacokinetics 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • E. E. Ohnhaus
    • 1
    • 2
  • E. Nüesch
    • 1
  1. 1.Experimental Therapeutics Department, Biological and Medical Research DivisionSandoz Ltd.BaselSwitzerland
  2. 2.Inselspital Med. UniversitätsklinikBernSwitzerland

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