Summary
Elimination of the bacteriostatics tetracycline, doxycycline, methacycline, oxytetracycline, demethylchlortetracycline and chlortetracycline was studied in healthy control persons and in patients on long-term antiepileptic therapy. The half-life of doxycycline was significantly shorter in patients than in the controls. The half-lives of other tetracycline derivatives and their excretion in urine were not significantly different between the two groups. Accordingly, in order to maintain an adequate serum level of doxycycline it should be given twice daily to patients on long-term therapy with barbiturates, diphenylhydantoin or carbamazepine. The classical tetracycline derivatives studied may be administered according to conventional principles.
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References
Alestig, K.: Studies on the intestinal excretion of doxycycline. Scand. J. infect. Dis.6, 265–271 (1974)
Frey, H., Yrjänä, T.: Carbamazepine titers of epileptic patients. Scand. J. clin. Lab. Invest.25 (Suppl. 113), 90 (1970)
Jaffe, J.M., Colaizzi, J.L., Poust, R.J., McDonald, R.H., Jr.: Effect of altered urinary pH on tetracycline and doxycycline excretion in humans. J. Pharmacokinet. Biopharmaceut.1, 267–282 (1974)
Kohn, K.W.: Determination of tetracyclines by extraction of fluorescent complexes. Application to biological materials. Analyst. Chem.33, 862–866 (1961)
Lever, M.: Improved fluorometric determination of tetracyclines. Biochem. Med.6, 216–222 (1972)
Neuvonen, P.J., Gothoni, G., Hackman, R., af Björksten, K.: Interference of iron with the absorption of tetracyclines in man. Brit. med. J.1970 IV, 532–534
Neuvonen, P.J., Penttilä, O.: Interaction between doxycycline and barbiturates. Brit. med. J.1974 I, 535–536
Neuvonen, P.J., Turakka, H.: Inhibitory effect of various iron salts on the absorption of tetracycline in man. Europ. J. clin. Pharmacol.7, 357–360 (1974)
Penttilä, O., Neuvonen, P.J., Aho, K., Lehtovaara, R.: Interaction between doxycycline and some antiepileptic drugs. Brit. med. J.1974 II, 470–472
Price, K.E., Zolli, Z., Jr., Atkinson, J.C. Luther, H.G.: Antibiotic inhibitors. Antibiot. and Chemother.7, 672–688 (1957)
Remmer, H.: Induction of drug metabolizing enzyme system in the liver. Europ. J. clin. Pharmacol.5, 116–136 (1972)
Schach von Wittenau, M., Twomey, T.M.: The disposition of doxycycline by man and dog. Chemotherapy (Basel)16, 217–228 (1971)
Waisbren, B.A., Hueckel, J.S.: Reduced absorption of aureomycin caused by aluminium hydroxide gel. Proc. Soc. exp. Biol. (N.Y.)73, 73–74 (1950)
Walter, A.M., Heilmeyer, L.: Antibiotika-Fibel, pp. 260–297. Stuttgart: Georg Thieme Verlag 1969
Vedsö, S., Rud, C., Place, J.F.: Determination of phenytoin in serum in the presence of barbiturates, sulthiame and ethosuximid by thin layer chromatography. Scand. J. clin. Lab. Invest.23, 175–180 (1969)
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Neuvonen, P.J., Penttilä, O., Lehtovaara, R. et al. Effect of antiepileptic drugs on the elimination of various tetracycline derivatives. Eur J Clin Pharmacol 9, 147–154 (1975). https://doi.org/10.1007/BF00614011
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DOI: https://doi.org/10.1007/BF00614011