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Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man


A possible interaction between zinc sulphate and tetracycline or doxycycline was examined in a cross-over study in seven volunteers. A single dose of zinc sulphate (45 mg Zn++) was given simultaneously with tetracycline hydrochloride (500 mg) or doxycycline chloride (200 mg). The serum concentration of tetracycline, the area under the serum tetracycline concentration-time curve and the excretion of tetracycline in urine were reduced by about 30% (p<0.05) from the respective control values. The absorption of doxycycline was not influenced significantly by zinc sulphate. The clinical significance of the zinc-tetracycline interaction seems to be of limited importance.

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Penttilä, O., Hurme, H. & Neuvonen, P.J. Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man. Eur J Clin Pharmacol 9, 131–134 (1975).

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Key words

  • Drug interaction
  • drug absorption
  • zinc sulphate
  • tetracycline
  • doxycycline