European Journal of Clinical Pharmacology

, Volume 24, Issue 1, pp 67–69 | Cite as

Comparison of quazepam, flunitrazepam and placebo as single-dose hypnotics before surgery

  • E. Wickstrøm
  • C. Allgulander


The hypnotic effect and tolerance of quazepam (Sch 16134) 15 and 30 mg, flunitrazepam 1 and 2 mg and placebo were evaluated in a one-night, randomized, double-blind, parallel group study of 100 hospitalized patients, who were to undergo a planned operation on the following day. All active drugs were rated as superior to placebo by the physician. Subjectively, quazepam 30 mg and flunitrazepam 1 and 2 mg were superior to placebo. Hangover effects were not distinguishable from placebo. Vigilance and ataxia tests were not altered by any of the drugs.

Key words

quazepam flunitrazepam hypnotic double-blind study preoperative patients side effects 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • E. Wickstrøm
    • 1
    • 2
  • C. Allgulander
    • 1
    • 2
  1. 1.Department of Surgery, Ullevål HospitalUniversity of OsloNorway
  2. 2.Pharmaceutical Research DivisionSchering CorporationBloomfieldUSA

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