European Journal of Clinical Pharmacology

, Volume 24, Issue 1, pp 67–69 | Cite as

Comparison of quazepam, flunitrazepam and placebo as single-dose hypnotics before surgery

  • E. Wickstrøm
  • C. Allgulander
Originals

Summary

The hypnotic effect and tolerance of quazepam (Sch 16134) 15 and 30 mg, flunitrazepam 1 and 2 mg and placebo were evaluated in a one-night, randomized, double-blind, parallel group study of 100 hospitalized patients, who were to undergo a planned operation on the following day. All active drugs were rated as superior to placebo by the physician. Subjectively, quazepam 30 mg and flunitrazepam 1 and 2 mg were superior to placebo. Hangover effects were not distinguishable from placebo. Vigilance and ataxia tests were not altered by any of the drugs.

Key words

quazepam flunitrazepam hypnotic double-blind study preoperative patients side effects 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bond AJ, Lader MH (1973) The residual effects of flurazepam. Psychopharmacologia 32: 223–235Google Scholar
  2. 2.
    Heinzl H (1980) Wirkungsvergleich von Triazolam (Halcion) und Flunitrazepam (Rohypnol) in der präoperativen Vorbereitungszeit. Schweiz Med Wochenschr 110: 1745–1748Google Scholar
  3. 3.
    Keighley MRB (1980) Evaluation of single-dose hypnotic treatment before elective operation. Br Med J 281 829–831Google Scholar
  4. 4.
    Roth T (1979) The effect of a single dose of quazepam (Sch 16134) on the sleep of chronic insomniacs. J Int Med Res 7: 583–587Google Scholar
  5. 5.
    Sundaresan PR (1979) Methodology for demonstrating sustained efficacy of hypnotics — comparative study of triazolam and flurazepam. Clin Pharmacol Ther 25: 391–398Google Scholar
  6. 6.
    Schwarz MA, Pstma E (1970) Metabolism of flurazepam, a benzodiazepine, in man and dog. J Pharm Sci 59: 1800–1806Google Scholar
  7. 7.
    Tietz E (1981) The acute effect of quazepam on the sleep of chronic insomniacs. Drug Res 31: 1683–1966Google Scholar
  8. 8.
    Uhthoff HK (1981) A clinical study of quazepam in hospitalized patients with insomnia. J Int Med Res 9: 288–291Google Scholar
  9. 9.
    Wickstrøm E, Giercksky KE (1980) Comparative study of zopiclone, a novel hypnotic, and three benzodiazepines. Eur J Clin Pharmacol 17: 93–99Google Scholar
  10. 10.
    Wickstrøm E (1974) Double-blind study of flunitrazepam (Ro 5-4200) and Mandrax. Anesthesist 23: 90–93Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • E. Wickstrøm
    • 1
    • 2
  • C. Allgulander
    • 1
    • 2
  1. 1.Department of Surgery, Ullevål HospitalUniversity of OsloNorway
  2. 2.Pharmaceutical Research DivisionSchering CorporationBloomfieldUSA

Personalised recommendations