Summary
A low dose combination pill containing levonorgestrel 150 µg and ethynylestradiol 50 µg was administered orally to 13 women. Based on their anthropometric index they were classed as well-nourished (Group A) or undernourished (Group B). Plasma levels of levonorgestrel at various intervals after dosing were analysed by a specific radioimmunoassay and its pharmacokinetic parameters were computed. Peak plasma levels in both groups occurred within 2 h and the absorption half-lives were also similar. The decline in plasma levonorgestrel showed a tri-exponential decline in all Group A women, whereas it was biphasic in most of Group B. The π t1/2 was lower in Group A women and the α-phase was found to be negligible in Group B. A significant positive correlation between elimination half-life (β t1/2) and some of the anthropometric indices suggests a possible role of nutritional status in the metabolic handling of levonorgestrel.
Similar content being viewed by others
References
Prasad KVS, Narasinga Rao BS, Sivakumar B, Prema K (1979) Pharmacokinetics of norethindrone in Indian women. Contraception 20: 77–90
Madhavan Nair K, Sivakumar B, Prema K, Narasinga Rao BS (1979) Pharmacokinetics of levonorgestrel in Indian women belonging to low socio-economic group. Contraception 20: 303–317
Thimmayamma BVS, Parvati Rau, Visweswara Rao K (1982) Socio-economic status, diet and nutrient adequacies of different population groups in urban and rural Hyderabad. Indian J Nutr Diet (in press)
Sankolli GM, Naik VK, Prasad KVS, Madhavan Nair K, Joshi UM (1979) Influence of antisera on the estimations of norethisterone and levonorgestrel. J Steroid Biochem 11: 1159–1163
Humpel M, Wendt H, Pommerenke G, Weiß C, Speck U (1978) Investigation of pharmacokinetics of levonorgestrel to specific consideration of a possible first-pass effect in women. Contraception 17: 207–220
Brenner PF, Mishell DR Jr, Stanczyk FZ, Goebelsmann U (1977) Serum levels of d-norgestrel, luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone in women during and following ingestion of combination oral contraceptives containing di-norgestrel. Am J Obstet Gynecol 129: 133–140
Weiner E, Victor A, Johansson EDB (1976) Plasma levels of d-norgestrel after oral administration. Contraception 14: 563–570
Victor A, Edqvist L, Lindberg P, Elamsson K, Johansson EDB (1975) Peripheral plasma levels of d-norgestrel in women after oral administration of d-norgestrel and when using intravaginal rings impregnated with dl-norgestrel. Contraception 12: 261–278
Stanczyk FZ, Hiroi M, Goebelsmann U, Brenner PF, Lumkin ME, Mishell DR Jr (1975) Radioimmunoassay of serum d-norgestrel in women following oral and intravaginal administration. Contraception 12: 279–298
Warren RJ, Fotherby K (1974) Radioimmunoassay of synthetic progestogens, norethisterone and norgestrel. J Endocrinol 62: 605–618
Uniyal JP, Buckshee U, Sharma U, Laumas KR (1976) Disappearance of [14, 15-3H] d,1-norgestrel from plasma and its distribution in the reproductive tract of women. Acta Endocrinol 82: 851–864
Humpel M, Wendt H, Dogs G, Weiß C, Rietz S, Speck U (1977) Intraindividual comparison of pharmacokinetic parameters of d-norgestrel, lynestrenol and cyproterone acetate in six women. Contraception 16: 199–215
Madhavan Nair K, Sivakumar B, Narasinga Rao BS (1981) Effect of food restriction (undernutrition) on pharmacokinetics of levonorgestrel in rabbits. Contraception 23: 549–561
Gallegos AJ, Gonzales-Diddi M, Merino G, Martinez-Manautou J (1970) Tissue localization of radioactive chlormadinone acetate and progesterone in the human. Contraception 1: 151–161
Hendles SM, Galand N, Schwers J (1972) Metabolism of orally administered d-norgestrel in women. Acta Endocrinol 71: 557–568
Prasad AS, Moghissi KS, Lei KY, Oberleas D, Styker JC (1977) Effect of oral contraceptives on micronutrients and changes in trace elements due to pregnancy. In: Moghissi KS, Evans TN (eds) Nutritional impacts on women. Harper and Row, New York, pp 160–188
Bamji MS, Prema K, Ramalakshmi BA, Ahmed F, Jacob CM (1979) Oral contraceptive use and vitamin nutrition status of malnourished women — effects of continuous and intermittent vitamin supplements. J Steroid Biochem 11: 487–491
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nair, K.M., Sivakumar, B., Prema, K. et al. Pharmacokinetics of levonorgestrel in Indian women. Eur J Clin Pharmacol 24, 255–259 (1983). https://doi.org/10.1007/BF00613828
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00613828