Summary
The pharmacokinetic profile of Sobrerol, a mucolytic drug, has been studied in patients with acute exacerbations of chronic bronchitis and dense sputum. In addition to measurement of serum and urine levels, the concentration in bronchial mucus was also examined, and their correlation was calculated. Mass fragmentographic analysis was used to assay free sobrerol and its principal urinary metabolites hydrated carvone and glucuronidated sobrerol. After the doses and administration routes used, there appeared to be accumulation of sobrerol in bronchial mucus. This is a feature of great interest and value for a drug which has the specific action of liquefying mucus.
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References
Dotta F, Bianchi A (1971) Il sobrerolo nel trattamento delle broncopneumopatie croniche ostruttive. Policlinico 78: 82–90
Balzano E, De Gaetani G (1972) Il sobrerolo nel trattamento delle flogosi broncopolmonari acute e croniche. Minerva Med 63: 1–8
Bosisio E, Sergi M, Nunziante A, Baudin E (1973) Azione secretolitica del sobrerolo e miglioramento della ventilazione polmonare in soggetti affetti da TBC polmonare cronica associata a bronchite cronica. G Ital Mal Torace 25: 145–160
Orlandi O, Vercellino A, Bruna S, Perino A (1973) Osservazioni cliniche su di un nuovo broncodisostruente di sintesi: il sobrerolo. Gaz Med Ital 132: 8–13
Marchioni CF, Scuri R, Morelli C, Baldini EV, Bisetti A (1979) Fluidifying activity of dl sobrerol in cronic bronchopaties. (Double-blind crossover trial) VI Asia-Pacific Congress on Diseases of the Chest. Bombay 18–22 November
Pouchelle E, Girard F, Zahm JM (1976) Rheologie des secretions bronchiques et transport muco-ciliare. Bull Europ Physiopathol Res 12: 771–779
Fumagalli G, Clini V, Guadagni L, Zagni S (1977) Studio clinico sulla proprietà muco-fluidificante del sobrerolo in soggetti broncopneumopatici cronici. 3rd European Congress on thorax diseases. Round Table on Secretolytic Drugs. Roma 22 July
Mattar G, de Barros LCM (1976) Avaliacao clinica de un novo farmaco, OPR-S/109, no tratamento dos processos distrutivos da arvore respiratoria por hipersecrecao. Folia Med 72[4]: 1–5
de Oliveira Netto NV, Diegues A (1976) Estudo aberto nao comparativo do PR-S/109, no tratamento das broncopatias obstrutivas por secrecoes. Folia Med 72[4]: 6–12
Allegra L, Bossi R, Braga PC (1981) Action of sobrerol on mucociliary transport. Respiration 42: 105–109
Braga PC (1981) Macrophotographic evidence of the activity of sobrerol on mucociliary transport in the frog's palate. Clin Trials J 18: 30–38
Cellari C, Scuri R, Pria R, Dalla Valle V (1973) Assorbimento ed escrezione del sobrerolo nel ratto. Atti Acad Med Lomb 28: 1–7
Homstedt B, Palmer L (1973) Mass fragmentography: principles, advantages and future possibilities. In: Costa E, Holmstedt B (eds) Advances in biochemical psychopharmacology, Vol 7. Raven Press, NY, pp 1–12
Bergogne-Berezin E, Morel C, Even P (1978) Pharmacocinetique des antibiotiques dans les voies respiratoires. Nouv Presse Med 7: 2831–2836
Bergogne-Berezin E, Lambert-Zechovsky N, Kafe H (1976) Etude pharmacocinetique comparative de divers antibiotiques dans les secretions bronchiques. Med Mal Infect 6: 134–137
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Braga, P.C., De Angelis, L., Bossi, R. et al. Pharmacokinetics of Sobrerol in chronic bronchitis. Eur J Clin Pharmacol 24, 209–215 (1983). https://doi.org/10.1007/BF00613819
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DOI: https://doi.org/10.1007/BF00613819