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Systolic time intervals: The effect of stroke volume in healthy young men

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Summary

1. Positional change and exercise were used to gain a range of heart rates and stroke volumes in 20 healthy male subjects, and a regression plane computed for the 3 principal systolic time intervals. The addition of stroke volume as a second physiological variable was shown to result in an increase in the coefficient of determination of 13% for the LVET and 10% for the PEP. The QS2 was found to be dependent only on heart rate.

It is concluded from this preliminary study that the addition of stroke volume and the derivation of a planar regression equation would allow calculation of potentially more useful index values for the LVET and PEP.

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References

  • Baker LE, Judy WV, Geddes LE, Langley FM, Hill DW (1971) The measurement of cardiac output by means of electrical impedance. Cardiovasc Res Cent Bull 9: 135–145

    Google Scholar 

  • Balasubramanian V, Mathew OP, Arun Behl, Tewari SC, Hoon RS (1978) Electrical impedance cardiogram in derivation of systolic time intervals. Brit Heart J 40: 268–275

    Google Scholar 

  • Denniston JC, Maher JT, Reeves JT, Cruz JC, Cymerman A, Grover RF (1976) Measurement of cardiac output by electrical impedance at rest and during exercise. J Appl Physiol 40 [1]: 91–95

    Google Scholar 

  • Garrod AH (1874–75) On some points connected with the circulation of the blood, arrived at from a study of the sphygmograph trace. Proc R Soc 23: 140

    Google Scholar 

  • Gibson DG (1978) Use of the systolic time intervals in clinical pharmacology. Br J Clin Pharmacol 6: 97–102

    Google Scholar 

  • Hildebrand FB (1956 and 1974) Introduction to numerical analysis. Tata McGraw-Hill, New York

    Google Scholar 

  • Hill DW, Thompson FD (1975) The effect of haematocrit on the resistivity of human blood at 37° C and 100 kHz. Med Biol Eng 13: 182–186

    Google Scholar 

  • Jones WB, Foster GL (1964) Determinants of duration of left ventricular ejection in normal young men. J Appl Physiol 19: 279–283

    Google Scholar 

  • Judy WV, Langley FM, McCowen KD, Stinnett DM, Baker LE, Johnson PC (1969) Comparative evaluation of the thoracic impedance and isotope dilution methods for measuring cardiac output. Aerosp Med 532–536

  • Keim HJ, Wallace JM, Thurston H, Case DB, Drayer JIM, Laragh JH (1976) Impedance cardiography for determination of stroke index. J Appl Physiol 41 [51]: 797–799

    Google Scholar 

  • Kinnen E (1970) Cardiac output from transthoracic impedance variations. Ann NY Acad Sci 170: 747–756

    Google Scholar 

  • Lababidi Z, Ehmke DA, Durnin RE, Leaverton PE, Lauer RM (1970) The first derivative thoracic impedance cardiogram. Circulation: 61: 651–658

    Google Scholar 

  • Naggar CZ, Dobnik DB, Flessas AP, Kripke BJ, Ryan TJ (1975) Accuracy of the stroke index as determined by the transthoracic electrical impedance method. Anesthesiology 42 [2]: 201–205

    Google Scholar 

  • Pate TD, Baker LE, Rosborough JP (1975) The simultaneous comparison of the electrical impedance method for measuring stroke volume and cardiac output with four other methods. Cardiovasc Res Center Bull 12 [2]: 39–52

    Google Scholar 

  • Rasmussen JP, Sorensen B, Kann T (1975) Evaluation of impedance cardiography as a non-invasive means of measuring systolic time intervals and cardiac output. Acta Anaesthesial Scand 19: 210–218

    Google Scholar 

  • Van der Hoeven GMA, Clerens PJA, Donders JJH, Beneken JEW, Vonk JTC (1977) A study of systolic time intervals during uninterrupted exercise. Br Heart J 39: 242–254

    Google Scholar 

  • Vanfraechem JHP (1979) Stroke volume and systolic time interval adjustments during bicycle exercise. J Appl Physiol 46 [3]: 588–592

    Google Scholar 

  • Weissler AM, Harris WS, Schoenfeld CD (1968) Systolic time intervals in heart failure in man. Circulation 37: 149–159

    Google Scholar 

  • Yu-Tang S, Wen-Ti S (1979) Comparative study on measurement of stroke volume by impedance method and electromagnetic flow method. Chin Med J 92 [2]: 79–84

    Google Scholar 

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Staniforth, D.H. Systolic time intervals: The effect of stroke volume in healthy young men. Eur J Clin Pharmacol 24, 179–183 (1983). https://doi.org/10.1007/BF00613814

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  • DOI: https://doi.org/10.1007/BF00613814

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