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European Journal of Clinical Pharmacology

, Volume 14, Issue 5, pp 361–366 | Cite as

Pharmacokinetics of furosemide in gestosis of pregnancy

  • E. Riva
  • P. Farina
  • G. Tognoni
  • S. Bottino
  • C. Orrico
  • G. Pardi
Article

Summary

Furosemide 50 mg was administered orally and intravenously to twelve gestotic women for brief periods as a part of a randomized, multicentre clinical trial comparing the efficacy of bed rest and pharmacological treatment. The pharmacokinetic profile was investigated using a gas-liquid chromatographic technique. The plasma half-life after oral and intravenous administration was 115±37.1 and 71.8±26.3 min and plasma clearance was 153±48 and 152±23 ml/min, respectively (mean±SD). Comparative data from healthy pregnant women cannot be obtained for ethical reasons. The results show that gestosis has only a marginal if any effect on the kinetics of furosemide in comparison with published kinetic parameters in healthy volunteers and patients with renal failure. The new-born babies where checked for side effects according to a protocol in use in a larger regional surveillance programme. No clinical side-effects were attributable to furosemide, but the small size of the group does not permit any definitive conclusions about this aspect.

Key words

Furosemide gestosis of pregnancy pharmacokinetics 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • E. Riva
    • 1
  • P. Farina
    • 1
  • G. Tognoni
    • 1
  • S. Bottino
    • 2
  • C. Orrico
    • 2
  • G. Pardi
    • 2
  1. 1.Istituto di Ricerche Farmacologiche “Mario Negri”MilanItaly
  2. 2.I Clinica Ostetrica-Ginecologica L. MangiagalliUniversità di MilanoMilanItaly

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