European Journal of Clinical Pharmacology

, Volume 14, Issue 5, pp 351–355 | Cite as

Influence of food on the absorption of acetylsalicylic acid from enteric-coated dosage forms

  • C. Bogentoft
  • I. Carlsson
  • G. Ekenved
  • A. Magnusson
Article

Summary

The absorption of acetylsalicylic acid (ASA) from two different enteric-coated dosage forms, tablets (Premaspin) and granules (Reumyl®), was studied in healthy volunteers under fasting and non-fasting conditions by following the plasma concentration and urine recovery of salicylates after single doses of ASA 1 g. Conventional tablets (Aspirin®) were used as the reference. Under fasting conditions the absorption of ASA from the two different enteric-coated preparations was complete. Taken with food the enteric-coated tablets gave much lower plasma concentrations than under fasting conditions, and absorption was not complete in all subjects. In contrast, absorption from the enteric-coated granules was not influenced by the intake of food. It was concluded that enteric-coated granules of ASA permit more reproducible absorption than enteric-coated tablets.

Key words

Acetylsalicylic acid aspirin enteric-coating absorption fasting food 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • C. Bogentoft
    • 1
  • I. Carlsson
    • 1
  • G. Ekenved
    • 1
  • A. Magnusson
    • 1
  1. 1.Research LaboratoriesAB HässleMölndalSweden

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