Journal of Comparative Physiology A

, Volume 156, Issue 1, pp 145–152 | Cite as

Circadian rhythms of house sparrows are phase-shifted by pharmacological manipulation of brain serotonin

  • Vincent M. Cassone
  • Michael Menaker


Fluoxetine, a specific serotonergic reuptake blocker and indirect agonist, and 5,6-dihydroxytryptamine, a serotonergic neurotoxin, affect the free-running locomotor rhythms of house sparrows,Passer domesticus. Both compounds caused phase-shifts in the circadian system that times locomotor activity of the birds. The magnitude and direction of the phase-shifts were dependent on the circadian phase of the drug administration, suggesting that serotonergic activity can modulate the circadian pacemaker of the house sparrow.


Serotonin Fluoxetine Locomotor Activity Drug Administration Circadian Rhythm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



serotonin, 5-hydroxytryptamine






suprachiasmatic nuclei


circadian time


compound action potential


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Breese G (1974) Chemical and immunochemical lesions by specific neurotoxic substances and antisera. In: Iversen L, Iversen S, Snyder S (eds) Handbook of psychopharmacology, vol 1. Plenum Publishing, New York, pp 137–189Google Scholar
  2. Cassone VM (1983) Neuroendocrine coupling within the avian circadian system. PhD dissertation, University of OregonGoogle Scholar
  3. Cassone VM, Moore RY (1984) The suprachiasmatic nuclei of the house sparrow,Passer domesticus. Soc Neurosci Abstr 10:500Google Scholar
  4. Cassone VM, Lane RF, Menaker M (1983) Daily rhythms of serotonin metabolism in the medial hypothalamus of the chicken: effects of pinealectomy and exogenous melatonin. Brain Res 279:129–134Google Scholar
  5. Corrent G, Eskin A, Kay I (1982) Entrainment of the circadian rhythm from the eye ofAplysia: role of serotonin. Am J Physiol 242:R326-R332Google Scholar
  6. Daan S, Pittendrigh CS (1976) A functional analysis of circadian pacemakers in nocturnal rodents. II. The variability of phase response curves. J Comp Physiol 106:253–266Google Scholar
  7. Ebihara S, Kawamura K (1981) The role of the pineal and the suprachiasmatic nuclei in the control of circadian rhythms of the Java sparrow,Padda orizivora. J Comp Physiol 141:207–214Google Scholar
  8. Eskin A (1971) Some properties of the system controlling the circadian activity rhythm of sparrows. In: Menaker M (ed) Biochronometry. Natl. Acad Sci, Washington DC, pp 55–60Google Scholar
  9. Eskin A (1979) Circadian system of theAplysia eye. Fed Proc 38:2573–2579Google Scholar
  10. Fuller RW, Wong DT (1977) Inhibition of serotonin reuptake. Fed Proc 36:2154–2158Google Scholar
  11. Fuxe K (1965) Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine nerve terminals in the central nervous system. Acta Physiol Scand 64 (Suppl 247): 37–85Google Scholar
  12. Honma K, Watanabe K, Hiroshige T (1979) Effects of parachlorophenylalanine and 5,6-dihydroxytryptamine on the free-running locomotor activity and corticosterone in the rat exposed to constant light. Brain Res 169:531–544Google Scholar
  13. Jouvet M (1972) The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. Erg Physiol 64:166–307Google Scholar
  14. Key BJ, Marley E (1962) The effect of the sympathomimetic amines on behavior and electrocortical activity of the chicken. Electroenceph Clin Neurophysiol 14:90–105Google Scholar
  15. Kostowski W, Gialcone E, Garattini S, Valzalli L (1968) Studies on behavioral and biochemical changes in rats after lesions of midbrain raphe. Eur J Pharmacol 4:17–22Google Scholar
  16. Martin JT, El Halawani M, Phillips RE (1982) Diurnal variation in hypothalamic monoamines and plasma corticosterone in the turkey after inhibition of tyrosine and tryptophan hydroxylase. Neuroendocrinol 34:191–196Google Scholar
  17. Menaker M (1968) Light perception by extraretinal photoreceptors in the brain of the sparrow. Proc 76th Annu Conv Am Psych Assoc: 299–300Google Scholar
  18. Menaker M (1982) The search for principles of physiological organization in vertebrate circadian systems. In: Aschoff J, Daan S, Groos G (eds) Vertebrate circadian systems. Springer Heidelberg Berlin New York, pp 1–12Google Scholar
  19. Meyer DC (1978) Hypothalamic and raphe serotonergic systems in ovulation control. Endocrinology 103:1034–1067Google Scholar
  20. Moore RY (1981) Methods for selective, restricted lesion placement in the central nervous system. In: Neuroanatomical Tract-Tracing Methods. Plenum Publishing, NY, pp. 55–86Google Scholar
  21. Moore RY (1982) Organization and function of a central nervous system circadian oscillator: the suprachiasmatic hypothalamic nucleus. Fed Proc 42:2783–2789Google Scholar
  22. Mouret J (1982) Sleep circadian rhythms in the rat: one clock or two? In: Aschoff J, Daan S, Groos G (eds) Vertebrate circadian systems. Springer Heidelberg Berlin New York, pp 242–249Google Scholar
  23. Pittendrigh CS (1981) Circadian systems: entrainment. In: Aschoff J (ed) Biological rhythms (Handbook of behavioral neurobiology, vol 4). Plenum Press, New York London, pp 95–124Google Scholar
  24. Rusak B, Zucker I (1979) Neural regulation of circadian rhythms. Physiol Rev 59:449–526Google Scholar
  25. Saavedra JM (1977) Distribution of serotonin and synthesizing enzymes in discrete areas of the brain. Fed Proc 36:2134–2141Google Scholar
  26. Simpson SM, Follett BK (1981) Pineal and hypothalamic pacemakers: their role in regulating circadian rhythms in Japanese quail. J Comp Physiol 144:381–389Google Scholar
  27. Spooner CE, Winters WD (1967) The influence of centrally active amine-induced blood pressure changes in electroencephalogram and behavior. Int J Neuropharmacol 6:109–118Google Scholar
  28. Takahashi JS, Menaker M (1982) Role of the suprachiasmatic nuclei in the circadian system of the house sparrow,Passer domesticus. J Neurosci 2:815–822Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Vincent M. Cassone
    • 1
  • Michael Menaker
    • 1
  1. 1.Institute of NeuroscienceUniversity of OregonEugeneUSA

Personalised recommendations