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Journal of Comparative Physiology A

, Volume 156, Issue 1, pp 145–152 | Cite as

Circadian rhythms of house sparrows are phase-shifted by pharmacological manipulation of brain serotonin

  • Vincent M. Cassone
  • Michael Menaker
Article

Summary

Fluoxetine, a specific serotonergic reuptake blocker and indirect agonist, and 5,6-dihydroxytryptamine, a serotonergic neurotoxin, affect the free-running locomotor rhythms of house sparrows,Passer domesticus. Both compounds caused phase-shifts in the circadian system that times locomotor activity of the birds. The magnitude and direction of the phase-shifts were dependent on the circadian phase of the drug administration, suggesting that serotonergic activity can modulate the circadian pacemaker of the house sparrow.

Keywords

Serotonin Fluoxetine Locomotor Activity Drug Administration Circadian Rhythm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

5HT

serotonin, 5-hydroxytryptamine

5,6-DHT

5,6-dihydroxytryptamine

DMI

desmethylimipramine

SCN

suprachiasmatic nuclei

CT

circadian time

CAP

compound action potential

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Vincent M. Cassone
    • 1
  • Michael Menaker
    • 1
  1. 1.Institute of NeuroscienceUniversity of OregonEugeneUSA

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