European Journal of Clinical Pharmacology

, Volume 33, Issue 1, pp 77–79 | Cite as

Methylergometrine antagonizes 5 HT in the temporal artery

  • P. Tfelt-Hansen
  • I. Jansen
  • L. Edvinsson
Short Communications

Summary

Methylergometrine, the main metabolite of methysergide, has 40-times greater 5 HT antagonistic potency than methysergide in isolated segments of human temporal artery. It is suggested that methylergometrine is the “active” drug when methysergide is used in migraine prophylaxis, and that the two compounds should be compared in prophylactic trials in migraine.

Key words

methysergide methylergometrine 5-HT antagonism migraine therapy human temporal artery 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • P. Tfelt-Hansen
    • 1
  • I. Jansen
    • 2
  • L. Edvinsson
    • 3
  1. 1.Department of NeurologyRigshospitaletCopenhagenDenmark
  2. 2.Department of Experimental ResearchMalmö General HospitalMalmöSweden
  3. 3.Department of Clinical Pharmacology and Internal MedicineUniversity HospitalLundSweden

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