European Journal of Clinical Pharmacology

, Volume 32, Issue 1, pp 111–113 | Cite as

Pharmacokinetics of ornidazole in neonates and infants after a single intravenous infusion

  • A. Turcant
  • J. C. Granry
  • P. Allain
  • M. Cavellat
Short Communications

Summary

The single dose pharmacokinetics of ornidazole has been evaluated in 12 neonates or infants (aged 1 to 42 weeks) after the infusion of 20 mg/kg over 20 min. Plasma disposition was described by a two-compartment open model. The distribution phase was short (T1/2 (1)=0.31 h) and was followed by an elimination phase (t1/2 (2)=14.67 h). The mean apparent volume of distribution was 0.96 l/kg−1. These results did not differ from data previous by reported in adults. Total plasma clearance was between 0.4 and 1.4 ml·min−1·kg−1. The plasma concentration 24 h after the infusion was 7.32 mg·l−1, which was above the minimum inhibitory concentration for clinically significant anaerobic bacteria. Based on the pharmacokinetic results and residual concentrations at 24 h, a single daily infusion of ornidazole 20 mg·kg−1 appears adequate for therapy in neonates and infants.

Key words

ornidazole neonates pharmacokinetics intravenous infusion 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Schwartz DE, Jeunet F (1976) Comparative studies of ornidazole and metronidazole in man. Chemotherapy 22: 19–29Google Scholar
  2. 2.
    Delion F, Thebault JJ, Singlas E (1985) Ornidazole: Une ou deux administrations par jour? J Pharm Clin 4: 301–307Google Scholar
  3. 3.
    Merdjan H, Bonnat C, Singlas E et al (1983) Measurement of ornidazole by high-performance liquid chromatography. J Chromatogr 273: 475–480Google Scholar
  4. 4.
    Johnston A, Woollard RC (1983) STRIPE: An interactive computer program for the analysis of drug pharmacokinetics. J Pharmacol Methods 9: 193–199Google Scholar
  5. 5.
    Palmu A, Renkonen OV, Aromaa U (1979) Ornidazole and anaerobic bacteria: in vitro sensitivity and effects on wound infections after appendectomy. J Infect Dis 139: 586–589Google Scholar
  6. 6.
    Vincent-Ballereau F, Lafaix CH (1982) Les 5 nitro-imidazoles dans le traitement et la prévention des infections à anaerobies Rev Med 4: 131–137Google Scholar
  7. 7.
    Wust J (1977) Susceptibility of anaerobic bacteria to metronidazole, ornidazole and tinidazole, and routine susceptibility testing by standardized methods. Antimicrob Chemother 11: 631–637Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Turcant
    • 1
  • J. C. Granry
    • 2
  • P. Allain
    • 1
  • M. Cavellat
    • 2
  1. 1.Laboratoire de PharmacologieCentre Hospitalier UniversitaireAngersFrance
  2. 2.Unité d'Anesthésie et de Réanimation Pédiatrique, Department Anesthésie-RéanimationCentre Hospitalier UniversitaireAngersFrance

Personalised recommendations