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European Journal of Clinical Pharmacology

, Volume 24, Issue 4, pp 475–478 | Cite as

Visual analogue scale and the analysis of analgesic action

  • H. Quiding
  • S. O. Häggquist
Originals

Summary

A double-blind randomized trial was carried out in 90 male patients suffering from pain after meniscectomy. The patients received a single dose of paracetamol 1 000 mg plus codeine 60 mg, paracetamol 1 000 mg, codeine 60 mg, or placebo. The tablets were taken when needed after surgery and the postoperative pain was recorded on a visual analogue scale. Over a period of 4 h the efficacy of the drugs was calculated in terms of pain intensity, pain intensity difference and percentage pain reduction. The greatest effect was obtained in patients taking the paracetamol plus codeine combination. Statistical analysis was carried out by use both of parametric and non-parametric procedures. The results suggest that pain reduction is a valuable measurement of analgesic efficacy and that non-parametric assumptions are preferable in the statistical analysis of analgesic activity.

Key words

codeine paracetamol pain analgesic activity evaluation procedure visual analogue scale 

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References

  1. 1.
    Huskisson EC (1974) Measurement of pain. Lancet 2: 1127–1131Google Scholar
  2. 2.
    Kremer E, Atkinson JH, Ignelzi RJ (1981) Measurement of pain: Pain preference does not confund pain measurement. Pain 10: 241–248Google Scholar
  3. 3.
    Scott J, Huskisson EC (1976) Graphic representation of pain. Pain 2: 175–184Google Scholar
  4. 4.
    Ohnhaus EE, Adler R (1975) Methodological problems in the measurement of pain: A comparison between the verbal rating scale and the visual analogue scale. Pain 1: 379–384Google Scholar
  5. 5.
    Revill SI, Robinson JO, Rosen M, Hogg MIJ (1976) The reliability of a linear analogue for evaluating pain. Anaesthesia 31: 1191–1198Google Scholar
  6. 6.
    Maxwell C (1978) Sensitivity and accuracy of the visual analogue scale: a psychophysical classroom experiment. Br J Clin Pharmacol 6: 15–24Google Scholar
  7. 7.
    Welch BL (1947) The generalization of student's problem when several different population variances are involved. Biometrika 34: 28Google Scholar
  8. 8.
    Carmer SG, Swanson MR (1973) An evaluation of ten pair-wise multiple comparison procedures by monte carlo methods. J Am Stat Assoc 68: 66–74Google Scholar
  9. 9.
    Eddy NB, Friebel H, Hahn K-J, Halbach H (1970) Codeine and its alternatives for pain and cough relief. World Health Organisation, Geneva, p 26Google Scholar
  10. 10.
    Quiding H, Oksala E, Happonen R-P, Lehtimäki K, Ojala T (1981) The visual analogue scale in multiple dose evaluations of analgesics. J Clin Pharmacol 21: 424–429Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • H. Quiding
    • 1
    • 2
  • S. O. Häggquist
    • 1
    • 2
  1. 1.Medical DepartmentAstra Läkemedel ABSödertäljeSweden
  2. 2.Department of Orthopaedic SurgeryCentral HospitalFalunSweden

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