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The effects of the 5 HT2 antagonist ketanserin in adult atopic asthma

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Summary

We have studied eight adult atopic asthmatic patients in a randomized double-blind, placebo-controlled, cross-over trial in order to examine the effects of the 5 HT2 antagonist ketanserin on airways function (FEV1, FVC, V50(χ), and V25(π)).

Ketanserin did not significantly change resting bronchomotor tone. Treadmill exercise caused a similar maximal percentage fall in FEV1 after both drug [16.8 (3.7)%] and placebo [19.2 (4.2)%]; ketanserin did not significantly attenuate bronchoconstriction, measured over a 20-min period after exercise.

These results suggest that 5 HT2 receptors do not play a major role in the control of resting bronchomotor tone or in exercise-induced bronchoconstriction in adult atopic asthmatic patients.

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Authors and Affiliations

  1. MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK

    D. J. Stott & S. G. Ball

  2. Department of Respiratory Medicine, Western Infirmary, Glasgow, UK

    J. A. Roberts, N. C. Thomson & S. G. Ball

  3. Department of Geriatric Medicine, Gartnavel General Hospital, G12 0YN, Glasgow, UK

    D. J. Stott

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  1. D. J. Stott
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  2. J. A. Roberts
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  3. N. C. Thomson
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  4. S. G. Ball
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Stott, D.J., Roberts, J.A., Thomson, N.C. et al. The effects of the 5 HT2 antagonist ketanserin in adult atopic asthma. Eur J Clin Pharmacol 35, 209–212 (1988). https://doi.org/10.1007/BF00609255

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  • DOI: https://doi.org/10.1007/BF00609255

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