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European Journal of Clinical Pharmacology

, Volume 36, Issue 2, pp 209–211 | Cite as

Transcutaneous absorption of naproxen gel

  • F. A. van den Ouweland
  • P. C. Eenhoorn
  • Y. Tan
  • F. W. J. Gribnau
Short Communications

Summary

The kinetics of naproxen was studied in healthy volunteers after cutaneous application of gels containing 5 and 10% of the drug. Bioavailability was estimated from serum concentration and cumulative urinary metabolite excretion data, both determined up to 96 hours after drug administration.

The mean bioavailability after the 10% gel was 1.1% (serum data) and 1.0% (urine data), and after the 5% gel it was 2.1% (serum data) and 1.8% (urine data).

Despite the small amount of naproxen absorbed, a potential pharmacological effect, due to cutaneous accumulation of the drug following topical administration, may be suggested from the course of the serum concentration-time curves.

Key words

naproxen transcutaneous absortion non-steroidal anti-inflammatory drug topical application pharmacokinetics 

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References

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    Van Den Ouweland FA, Gribnau FWJ, Van Ginneken CAM, Tan Y, Van De Putte LBA (1988) Naproxen kinetics and disease activity in rheumatoid arthritis: a within-patient study. Clin Pharmacol Ther 43: 79–85PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • F. A. van den Ouweland
    • 1
    • 2
  • P. C. Eenhoorn
    • 3
  • Y. Tan
    • 1
  • F. W. J. Gribnau
    • 1
  1. 1.Department of Medicine, Division of Clinical PharmacologyUniversity Hospital Sint RadboudNijmegenThe Netherlands
  2. 2.Department of EpidemiologyErasmus University Medical SchoolRotterdamThe Netherlands
  3. 3.Sarva-Syntex NederlandRijswijkThe Netherlands

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