Summary
Two related and interlocking spheres of activity with respect to combination drugs, the sphere of theoretical debate and the sphere of actual use, must be considered. Debate and learned opinion serves to strengthen the scientific basis for the development and prescribing of combination drugs. Physician preferences and actual usage patterns around the world, among both specialists and general practitioners, show that combination therapy is considered good therapy in the majority of countries. An examination of the registration statistics for combinations vs. single entity drugs shows that combination drugs are welcome additions to therapy in an era of scientific sophistication and are acceptable under the scrutiny of today's modern review process.
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References
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Helfand, W.H. Worldwide patterns of combination drug usage. Eur J Clin Pharmacol 16, 221–228 (1979). https://doi.org/10.1007/BF00608399
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DOI: https://doi.org/10.1007/BF00608399