Summary
Blood pressure, heart rate, and plasma catecholamine concentrations were measured in 9 normotensive volunteers during a randomized cross-over study of oral nifedipine (10 mg×5) and placebo; measurements were made at rest and during maximal anaerobic exercise. At rest nifedipine reduced blood pressure and increased heart rate and plasma noradrenaline, whereas plasma adrenaline did not change. During exercise, the blood pressure response was similar in nifedipine and placebo treated subjects; however, heart rate was significantly higher with nifedipine. Plasma noradrenaline increased more during exercise in nifedipine-treated subjects. By contrast, nifedipine inhibited the increase in plasma adrenaline induced by exercise.
The results suggest that peripheral vasodilatation induced by nifedipine is responsible for increased sympathetic nerve activity, both at rest and during exercise, and that nifedipine inhibits adrenaline secretion in man.
References
Fleckenstein A, Tritthart H, Fleckenstein B (1969) A new group of competitive Ca antagonists (ipoveratril D 600, prenylamine) with highly potent inhibitory effects on excitation-contraction coupling in mammalian myocardium. Pflugers Arch 307: R 25
Trunet P, Lhoste F, Ansquer JC, Kestembaum S, Sabatier C, Tillement JP, Rapin M (1984) Decreased plasma epinephrine concentrations after glucose ingestion in man. Metabolism 33: 101–103
Lederballe-Pedersen O, Christensen NJ, Ramsch KD (1980) Comparison of acute effects of nifedipine in normotensive and hypertensive man. J Cardiovasc Pharmacol 2: 357–366
Leonetti G, Cuspidi C, Sampieri L, Terzoli L, Zanchetti A (1982) Comparison of cardiovascular, renal, and humoral effects of acute administration of two calcium channel blockers in normotensive and hypertensive subjects. J Cardiovasc Pharmacol 4: S 319–324
Millar JA, Mc Lean KA, Summer DJ, Reid Jl (1983) The effects of the calcium antagonist nifedipine on pressor and aldosterone responses to angiotensin II in normal man. Eur J Clin Pharmacol 24: 315–321
Hiramatsu K, Yamagischi F, Kubota T, Yamada T (1982) Acute effects of the calcium antagonist nifedipine on blood pressure, pulse rate, and the renin-angiotensin-aldosterone system in patients with essential hypertension. Am Heart J 104: 1346–1350
Axelrod J, Weinshilboum R (1972) Catecholamines. N Engl J Med 287: 237–242
Clausen JP (1976) Circulatory adjustements to dynamic exercise and effects of physical training in normal subjects and in patients with coronary artery disease. Progr Cardiovasc Dis 18: 459–495
Warren JB, Dalton N, Turner C, Clark TJ, Toseland PA (1984) Adrenaline secretion during exercise. Clin Sci 66: 87–90
Cryer PE (1980) Isotope derivative measurements of catecholamines in the study of human metabolic physiology and pathophysiology. A symposium. Metabolism 29: 1101–1105
Kindermann W, Schnabel A, Schmitt WM, Biro G, Cassens J, Weber F (1982) Catecholamines, growth hormone, cortisol, insulin and sex hormones in anaerobic and aerobic exercise. Eur J Appl Physiol 49: 389–399
Hamann SR, Blouin RA, Chang SL, Kaltenborn KE, Tan TG, Mc Allister RG (1984) Effects of hemodynamic changes on the elimination kinetics of verapamil and nifedipine. J Pharmacol Exp Ther 231: 301–305
Feely J (1984) Nifedipine increases and glyceryl trinitrate decreases apparent liver blood flow in normal subjects. Br J Clin Pharmacol 17: 83–85
Leier CV, Patrick TJ, Hermiller J, Dalpiazpacht K, Huss P, Magorien RD, Unverferth DV (1984) Nifedipine in congestive heart failure: Effects on resting and exercise hemodynamics and regional blood flow. Am Heart J 108: 1461–1468
Zelis R, Wichmann T, Starke K (1982) Inhibition of vascular noradrenaline release by diltiazem. Circulation 66 [Suppl II]: 139
Serfas D, Shoback DM, Lorell BH (1983) Phaeochromocytoma and hypertrophic cardiomyopathy: apparent suppression of symptoms and noradrenaline secretion by calcium-channel blockade. Lancet 1: 711–713
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Defer, G., Guezennec, Y.C. & Lhoste, F. Effect of nifedipine on plasma catecholamines in man at rest and during exercise. Eur J Clin Pharmacol 30, 727–729 (1986). https://doi.org/10.1007/BF00608224
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DOI: https://doi.org/10.1007/BF00608224