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Assessment of the relative safety of the beta-blockers ICI 141,292 and atenolol in patients with bronchial asthma

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Summary

ICI 141,292 is a β-blocker with β1-selective partial agonist activity. To study its cardioselectivity in humans, comparable β-blocking doses of 200 mg ICI 141,292 and 100 mg atenolol were given to 12 patients with stable bronchial asthma. Both drugs significantly reduced the midexpiratory flow rate at 50% of vital capacity, whereas no significant reduction in FEV1 or peak expiratory flow rate were observed. It is concluded that the cardioselectivity of ICI 141,292 did not differ significantly from that of atenolol. Since they both had a measurable effect on respiratory mechanics, they should probably not be prescribed in bronchial asthma, or only with the greatest possible caution.

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References

  1. Benson MK, Berril WT, Cruickshank JM, Sterling GS (1978) A comparison of four beta-adrenoceptor antagonists in patients with asthma. Br J Clin Pharmacol 5: 415–419

    Google Scholar 

  2. Berglund E, Birath G (1963) Spirometric studies in normal subjects. Acta Med Scand 2: 185–206

    Google Scholar 

  3. Bulow K, Arborelius M Jr, Christensson P, Lilja B (1978) Changes in volume at trapped gas in the lungs during provoked asthma followed by beta2-receptor stimulation. Respiration 36: 19–27

    Google Scholar 

  4. Christensson P, Arborelius M Jr, Kantto R (1981) Volume of trapped gas in lungs of healthy humans. J Appl Physiol 51: 172–175

    Google Scholar 

  5. Cotes JE, Hall AM (1970) The transfer factor for the lung; normal values in adults. In: Arcangeh P (ed) Normal values for respiratory function in man. Panminerva Medica, Torino, 1970

    Google Scholar 

  6. Decalmer PB, Chatterjee SS, Cruickshank JM (1978) Beta-blockers and asthma. Br Heart J 40: 184–189

    Google Scholar 

  7. Dolovich MB, Sanchis, Rossmann C (1976) Aerosol penetrance: A sensitive test for peripheral airways obstruction. J Appl Physiol 40: 468–471

    Google Scholar 

  8. Georg J (1955) The nitrogen clearance of the lungs. Scand J Clin Lab Invest 7: 308–319

    Google Scholar 

  9. Groth S, Lindell SE (1984) Bronchial reactivity and small airways dysfunction. Bull Europ Physiopathol Respir 20: 279–284

    Google Scholar 

  10. Hedensiterna G, Jorfeldt L, Bygdeman S (1981) Flow-volume curves in healthy non-smokers and in smokers. Clin Physiol 1: 339–348

    Google Scholar 

  11. Henningsen NC (1977) Personal communication. In: Hoffbrand BI (ed) Atenolol. Postgrad Med J 53 [Suppl 3]: p 149

    Google Scholar 

  12. Ingram RH Jr, McFadden ER Jr (1979) Predominantly large versus small airway responses in normal subjects. In: Sadoul P, Milic-Emil J (eds) Small airways in health and disease. Excerpta Medica, Amsterdam, pp 136–143

    Google Scholar 

  13. Kjellman B (1969) Ventilatory efficiency, capacity and lung volumes in healthy children. Scand J Clin Lab Invest 23: 19–29

    Google Scholar 

  14. Nadel JA (1979) Mechanisms of airway hyperirritability: Role of epithelial damage. In: Sadoul P, Milic-Emili J (eds) Small airways in health and disease. Excerpta Medica, Amsterdam, pp 68–73

    Google Scholar 

  15. Nadel JA, Teirney DF (1961) Effect of a previous deep inspiration on airway resistance in man. J Appl Physiol 16: 717–719

    Google Scholar 

  16. Pringle TH, O'Connor PC, McNeill AJ, Riddell JG, Shanks RG (1985) β-adrenoceptor blocking activity and cardioselectivity in man of ICI 141,292. Br J Clin Pharmacol 19/1: 137P-138P

    Google Scholar 

  17. Raine JM, Palazzo MG, Kerr JH, Sleight P (1981) Near fatal bronchospasm after oral nadolol in a young asthmatic and response to ventilation with halothane. Br Med J 282: 548–549

    Google Scholar 

  18. Simonsson BG, Jacobs FM (1967) Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airways disease. J Clin Invest 46: 1812–1818

    Google Scholar 

  19. Smith JH, Halliday SE (1983) Effects of selective (beta1 and beta2) and nonselective beta-adrenoceptor antagonists on the cardiovascular and metabolic responses to isoproterenol: Comparison with ICI 141,292. Earl DNC. J Pharmacol Exp Ther 226: 211–216

    Google Scholar 

  20. Thiringer G, Svedmyr N (1976) Interaction of orally administered metoprolol, practolol and propranolol with isoprenaline in asthmatics. Eur J Clin Pharmacol 10: 163–170

    Google Scholar 

  21. Vilsvik JS, Schaaning J (1976) Effect of atenolol on ventilatory and cardiac function in asthma. Br Med J 2: 453–455

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Physiology, The Finsen Institute, Copenhagen, Denmark

    S. Groth, P. Tønnesen, M. Asted, H. Dirksen & P. G. Sørensen

  2. the Department of Lung Medicine, Lyngby Hospital, Copenhagen, Denmark

    S. Groth, P. Tønnesen, M. Asted, H. Dirksen & P. G. Sørensen

Authors
  1. S. Groth
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  2. P. Tønnesen
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  3. M. Asted
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  4. H. Dirksen
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  5. P. G. Sørensen
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Groth, S., Tønnesen, P., Asted, M. et al. Assessment of the relative safety of the beta-blockers ICI 141,292 and atenolol in patients with bronchial asthma. Eur J Clin Pharmacol 30, 653–658 (1986). https://doi.org/10.1007/BF00608211

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  • DOI: https://doi.org/10.1007/BF00608211

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