Skip to main content
SpringerLink
Log in

Effect of sucralfate on the bioavailability of cimetidine

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

Twelve, healthy fasting, subjects received 200 mg cimetidine orally either with water or 1 g sucralfate in a randomized, single dose, two-way crossover study. Blood samples were taken for 12 h and urine was collected for 24 h. Cimetidine in plasma and urine was analysed by HPLC. There was no significant difference between the two treatments in peak plasma concentration, time to peak plasma concentration, area under the plasma concentration-time curve and urinary excretion. The results indicate that sucralfate did not reduce the bioavailability of cimetidine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Albin H, Vinçon G, Demotes-Mainard F, Begaud B, Bedjaoui A (1984) Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone. Eur J Clin Pharmacol 26: 271–273

    Google Scholar 

  2. Brogden RN, Heel RC, Speight TM, Avery GS (1984) Sucralfate: A review of its pharmacodynamic properties and therapeutic use in peptic ulcer disease. Drugs 27: 194–209

    Google Scholar 

  3. Gugler R, Brand M, Smogyi A (1981) Impaired cimetidine absorption due to antacids and metoclopramide. Eur J Clin Pharmacol 20: 225–228

    Google Scholar 

  4. Hurwitz A (1977) Antacid therapy and drug kinetics. Clin Pharmacokinet 2: 269–280

    Google Scholar 

  5. Kamali F, Fry JR, Smart HL, Bell GD (1985) A double-blind placebo controlled study to examine effects of sucralfate on paracetamol absorption. Br J Clin Pharmacol 19: 113–114

    Google Scholar 

  6. Lacz JP, Groschang AG, Giesing D, Browne R (1982) The effect of sucralfate on drug absorption in dogs. Gastroenterology 82: 5, 1108

    Google Scholar 

  7. Randolf WC, Osborne VL, Walkenstein S, Intoccia AP (1977) High-pressure liquid chromatographic analysis of cimetidine a histamine H2-receptor antagonist in blood and urine. J Pharm Sci 66: 1148–1150

    Google Scholar 

  8. Vinçon G, Fleury B, Demotes-Mainard F, Conri C, Albin H (1983) Influence de l'alimentation sur la biodisponibilité de la cimétidine. Thérapie 38: 607–612

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, Hôpital Pellgrin, Bordeaux, France

    H. Albin & G. Vincon

  2. Department of Gastroenterology Hôpital Haut-Lévêque, Pessac, France

    M. C. Lalague, P. Couzigou & M. Amouretti

Authors
  1. H. Albin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Vincon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. C. Lalague
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Couzigou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Amouretti
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Albin, H., Vincon, G., Lalague, M.C. et al. Effect of sucralfate on the bioavailability of cimetidine. Eur J Clin Pharmacol 30, 493–494 (1986). https://doi.org/10.1007/BF00607967

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00607967

Key words

Search

Navigation