European Journal of Clinical Pharmacology

, Volume 30, Issue 4, pp 493–494 | Cite as

Effect of sucralfate on the bioavailability of cimetidine

  • H. Albin
  • G. Vincon
  • M. C. Lalague
  • P. Couzigou
  • M. Amouretti
Short Communications

Summary

Twelve, healthy fasting, subjects received 200 mg cimetidine orally either with water or 1 g sucralfate in a randomized, single dose, two-way crossover study. Blood samples were taken for 12 h and urine was collected for 24 h. Cimetidine in plasma and urine was analysed by HPLC. There was no significant difference between the two treatments in peak plasma concentration, time to peak plasma concentration, area under the plasma concentration-time curve and urinary excretion. The results indicate that sucralfate did not reduce the bioavailability of cimetidine.

Key words

cimetidine sucralfate bioavailability 

References

  1. 1.
    Albin H, Vinçon G, Demotes-Mainard F, Begaud B, Bedjaoui A (1984) Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone. Eur J Clin Pharmacol 26: 271–273Google Scholar
  2. 2.
    Brogden RN, Heel RC, Speight TM, Avery GS (1984) Sucralfate: A review of its pharmacodynamic properties and therapeutic use in peptic ulcer disease. Drugs 27: 194–209Google Scholar
  3. 3.
    Gugler R, Brand M, Smogyi A (1981) Impaired cimetidine absorption due to antacids and metoclopramide. Eur J Clin Pharmacol 20: 225–228Google Scholar
  4. 4.
    Hurwitz A (1977) Antacid therapy and drug kinetics. Clin Pharmacokinet 2: 269–280Google Scholar
  5. 5.
    Kamali F, Fry JR, Smart HL, Bell GD (1985) A double-blind placebo controlled study to examine effects of sucralfate on paracetamol absorption. Br J Clin Pharmacol 19: 113–114Google Scholar
  6. 6.
    Lacz JP, Groschang AG, Giesing D, Browne R (1982) The effect of sucralfate on drug absorption in dogs. Gastroenterology 82: 5, 1108Google Scholar
  7. 7.
    Randolf WC, Osborne VL, Walkenstein S, Intoccia AP (1977) High-pressure liquid chromatographic analysis of cimetidine a histamine H2-receptor antagonist in blood and urine. J Pharm Sci 66: 1148–1150Google Scholar
  8. 8.
    Vinçon G, Fleury B, Demotes-Mainard F, Conri C, Albin H (1983) Influence de l'alimentation sur la biodisponibilité de la cimétidine. Thérapie 38: 607–612Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • H. Albin
    • 1
  • G. Vincon
    • 1
  • M. C. Lalague
    • 2
  • P. Couzigou
    • 2
  • M. Amouretti
    • 2
  1. 1.Department of Clinical PharmacologyHôpital PellgrinBordeauxFrance
  2. 2.Department of Gastroenterology Hôpital Haut-LévêquePessacFrance

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