European Journal of Clinical Pharmacology

, Volume 28, Issue 6, pp 713–716 | Cite as

Double blind study of the influence of co-dergocrine on platelet parameters in healthy volunteers

  • H. Sinzinger
Short Communications

Summary

In 20 healthy volunteers double-blind randomized study was done to examine the effect of codergocrine (Hydergin) on platelet function. All the volunteers were pretreated with 3×1 placebo for 1 week, followed by the randomized study in which 10 volunteers each received drug or placebo for 6 weeks. Various platelet function parameters, such as the peripheral platelet count, plasma thromboxane B2, platelet sensitivity to the antigaggregatory prostaglandins PGI2, PGE1 and PGD2, ADP-in-duced aggregation, collagen-induced aggregation, the WU-test, the platelet proteins platelet factor 4 and β-thromboglobulin, malondialdehyde, circulating endothelial cells and the intracellular c-AMP level in platelets were examined. Treatment with co-dergocrine decreased platelet activity to a significant extent, as shown by a number of platelet function parameters, such as thromboxane B2, WU-test, β-thromboglobulin, platelet factor 4, malondialdehyde and ADP-induced aggregation. The findings suggest that co-dergocrine might be able to decrease platelet activity and improve interaction with the walls of to a blood-vessel significant degree.

Key words

co-dergocrine platelet function platelet proteins prostaglandins aggregation 

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References

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • H. Sinzinger
    • 1
  1. 1.Atherosclerosis Research Group at the Department of Medical Physiology (ASF)University of Vienna and Atherosclerosis and Thrombosis Research Group (ATK) of the Austrian Academy of SciencesViennaAustria

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