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European Journal of Clinical Pharmacology

, Volume 28, Issue 6, pp 705–708 | Cite as

The effect of a 1-deoxynojirimycin derivative on post-prandial blood glucose and insulin levels in healthy black and white volunteers

  • P. H. Joubert
  • C. P. Venter
  • H. F. Joubert
  • I. Hillebrand
Originals

Summary

BAY m1099 (a 1-deoxynojirimycin derivative) is a glucose analogue which is an α-glucosidase inhibitor. Its effects on post-prandial blood glucose and insulin levels was compared with a placebo in 12 healthy male volunteers (6 Blacks and 6 Whites). It produced a similar, significant depression of post-prandial blood glucose and insulin leveles when the groups were assessed separately and when the data were pooled. Although blood insulin levels in Whites were higher than in Blacks, as previously reported, the difference was not statistically significant and did not appear to influence the response to the drug. BAY 1099 produced no objective or subjective untoward effects and appears to warrant further investigation as an adjuvant to dietary control of diabetes mellitus.

Key words

diabetes mellitus 1-deoxynojirimycin alpha-glucosidase inhibitors glucose insulin Whites Blacks 

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References

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • P. H. Joubert
    • 1
  • C. P. Venter
    • 1
  • H. F. Joubert
    • 2
  • I. Hillebrand
    • 3
  1. 1.Department of Pharmacology and TherapeuticsMedical University of Southern AfricaMedunsaSouth Africa
  2. 2.Department of Chemical PathologyMedical University of Southern AfricaMedunsaSouth Africa and Bayer Farma
  3. 3.ForschungszentrumWuppertalFederal Republic of Germany

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