European Journal of Clinical Pharmacology

, Volume 28, Issue 6, pp 705–708 | Cite as

The effect of a 1-deoxynojirimycin derivative on post-prandial blood glucose and insulin levels in healthy black and white volunteers

  • P. H. Joubert
  • C. P. Venter
  • H. F. Joubert
  • I. Hillebrand


BAY m1099 (a 1-deoxynojirimycin derivative) is a glucose analogue which is an α-glucosidase inhibitor. Its effects on post-prandial blood glucose and insulin levels was compared with a placebo in 12 healthy male volunteers (6 Blacks and 6 Whites). It produced a similar, significant depression of post-prandial blood glucose and insulin leveles when the groups were assessed separately and when the data were pooled. Although blood insulin levels in Whites were higher than in Blacks, as previously reported, the difference was not statistically significant and did not appear to influence the response to the drug. BAY 1099 produced no objective or subjective untoward effects and appears to warrant further investigation as an adjuvant to dietary control of diabetes mellitus.

Key words

diabetes mellitus 1-deoxynojirimycin alpha-glucosidase inhibitors glucose insulin Whites Blacks 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Jenkins DJA, Leeds AR, Gassul MA et al. (1977) Decrease in post-prandial insulin and glucose concentrations by guar and pectin. Ann Int Med 86: 20–23Google Scholar
  2. 2.
    Walton RJ, Sheriff IT, Noy GA et al. (1979) Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidase inhibitor. Br Med J 1: 220–221Google Scholar
  3. 3.
    Meyer BH, Müller FO, Grigoleit HG et al. (1983) Inhibition of starch absorption by tendamisate (an alpha-amylase inactivator). S Afr Med J 64: 248–285Google Scholar
  4. 4.
    Schmidt DD, Frommer W, Müller L et al. (1979) Glucosidase-Inhibitoren aus Bazillen. Naturwissenschaften 66: 584–585Google Scholar
  5. 5.
    Saunier B, Kilker RD, Tkacz JS et al. (1982) Inhibition of N-linked complex oligosaccharide synthesis by 1-deoxynojirimycin, an inhibitor of processing. J Biol Chem 23: 14155–14161Google Scholar
  6. 6.
    Rubenstein AH, Saftel HC, Miller K et al. (1969) Metabolic response to oral glucose in healthy South African White, Indian and African subjects. Br Med J 1: 748–751Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • P. H. Joubert
    • 1
  • C. P. Venter
    • 1
  • H. F. Joubert
    • 2
  • I. Hillebrand
    • 3
  1. 1.Department of Pharmacology and TherapeuticsMedical University of Southern AfricaMedunsaSouth Africa
  2. 2.Department of Chemical PathologyMedical University of Southern AfricaMedunsaSouth Africa and Bayer Farma
  3. 3.ForschungszentrumWuppertalFederal Republic of Germany

Personalised recommendations