European Journal of Clinical Pharmacology

, Volume 14, Issue 2, pp 105–109 | Cite as

Initial clinical experience of lorcainide (Ro 13-1042), a new antiarrhythmic agent

  • G. Cocco
  • C. Strozzi


Lorcainide is a promising antiarrhythmic agent that belongs to the class of local anesthetics. It was tested in 7 patients with malignant ventricular arrhythmias that were resistant to other antiarrhythmic agents. Lorcainide was effective in all cases (complete disappearance of arrhythmias in 6 cases and more than 50% disappearance in the 7th case), and the tolerance was within acceptable limits. The drug was effective at rest, as assessed by 24-h dynamic electrocardiographic monitoring, and during physical exercise. Longer studies with more patients are warranted, since the drug appears to be a promising antiarrhythmic agent.

Key words

Lorcainide antiarrhythmic agent ventricular arrhythmia 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • G. Cocco
    • 1
    • 2
  • C. Strozzi
    • 1
  1. 1.Institute of General Medical Clinics and Medical TherapeuticsUniversity of FerraraItaly
  2. 2.Hoffmann-La Roche & Co. Ltd.BasleSwitzerland

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