European Journal of Clinical Pharmacology

, Volume 12, Issue 4, pp 311–317 | Cite as

Pharmacokinetics of fluoride in man after single and multiple oral doses

  • J. Ekstrand
  • G. Alván
  • L. O. Boréus
  • A. Norlin
Originals

Summary

The doses of fluoride (F) recommended in the literature for caries prevention and for the treatment of osteoporosis vary. This partly reflects inadequate knowledge of F pharmacokinetics. In the present study various single and multiple oral doses of F were given to eight volunteers, who had a strictly controlled F intake in the diet. The resulting plasma and parotid saliva concentrations as well as urinary output of F were measured. The plasma data fitted a two-compartment open model with a β-slope half-life ranging between 2 and 9 h. Plasma clearance was 0.15±0.02 (SD) liter/kg/h. Data from the highest dose (10 mg) were fitted to both two- and three-compartment models, and there was no significant difference between them. Multiple doses of F 3.0 or 4.5 mg yielded steady state concentrations ranging from 54 to 145 ng/ml. About 50 per cent of the given dose was recovered in the urine, which is indicative of considerable accumulation in the body. The saliva F/plasma F concentration ratio was 0.64 with a coefficient of variation of 5%.

Key words

Fluoride single- and multiple dose kinetics plasma concentration urinary excretion saliva/plasma concentration ratio 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • J. Ekstrand
    • 1
    • 2
    • 3
  • G. Alván
    • 1
    • 2
    • 3
  • L. O. Boréus
    • 1
    • 2
    • 3
  • A. Norlin
    • 1
    • 2
    • 3
  1. 1.Department of Pharmacology and CariologyKarolinska InstituteStockholmSweden
  2. 2.Department of Clinical PharmacologyKarolinska HospitalStockholmSweden
  3. 3.Department of Clinical PharmacologyHuddinge HospitalStockholmSweden

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