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European Journal of Clinical Pharmacology

, Volume 20, Issue 2, pp 85–89 | Cite as

Prolonged Q-T interval and severe tachyarrhythmias, common features of sotalol intoxication

  • P. J. Neuvonen
  • E. Elonen
  • T. Vuorenmaa
  • M. Laakso
Originals

Summary

The findings in six patients admitted to hospital 0.5–4.5 h after the ingestion of an overdose of 2.4–8 g sotalol are described. In addition to bradycardia and hypotension, all patients had a considerably prolonged corrected Q-T interval, up to 172±8% of normal. Severe ventricular tachyarrhythmias occurred in five of the six patients, the risk was greatest up to 20 h after the ingestion of sotalol. The long Q-T interval returned to normal over 3 to 4 days, which is consistent with the long half-life of sotalol. In addition to its beta-blocking action, sotalol has marked electrophysiological properties of a Class III antiarrhythmic drugs, which are likely to be able to account for its observed effects. Special attention should be paid to the risk of severe ventricular arrhythmias in sotalol intoxications.

Key words

beta-blockers sotalol intoxication Q-T interval tachyarrhythmias 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • P. J. Neuvonen
    • 1
  • E. Elonen
    • 2
  • T. Vuorenmaa
    • 3
  • M. Laakso
    • 4
  1. 1.Department of Clinical PharmacologyUniversity of HelsinkiFinland
  2. 2.Third Department of MedicineUniversity of HelsinkiFinland
  3. 3.Department of MedicineUniversity of TurkuFinland
  4. 4.Department of MedicineUniversity of KuopioFinland

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