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European Journal of Clinical Pharmacology

, Volume 24, Issue 6, pp 769–772 | Cite as

Inhibition of postprandial colonic motility by sulpiride in patients with irritable colon

  • G. A. Lanfranchi
  • G. Bazzocchi
  • L. Marzio
  • M. Campieri
  • C. Brignola
Originals

Summary

Sulpiride, a benzamide derivative, selectively antagonizes dopaminergic receptors within and outside the central nervous system. Dopamine has previously been shown to increase colonic motility. In the present investigation the motor response of the pelvic colon to a standard 1000 calorie meal was studied in 12 patients with the irritable bowel syndrome. The meal induced a significant increase in motor activity, lasting for 1 h and greatest in the first 30 min. In 6 cases the administration of sulpiride 100 mg i.m. significantly reduced the postprandial increase in colonic motor activity. Thus dopaminergic receptors may be involved in the colonic motor response to food.

Key words

sulpiride gastrocolic reflex dopaminergic receptors irritable bowel syndrome 

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References

  1. 1.
    Anuras S (1981) Effect of dopamine on opossum duodenal smooth muscle. Gastroenterology 80: 51–54Google Scholar
  2. 2.
    Aune S, Stadaas JO (1972) The inhibitory effect of sulpiride on pentagastrin-stimulated gastric secretion. Scand J Gastroenterol 7: 713–715Google Scholar
  3. 3.
    Chowdhury AR, Lorber SH (1977) Effects of glucagon and secretine on food- or morphine-induced motor activity of the distal colon, rectum and anal sphyncter. Dig Dis 22: 775–780Google Scholar
  4. 4.
    Connell AM, Avery Jones F, Rowlands EN (1965) The motility of the pelvic colon. IV. Abdominal pain associated with colonic hypermotility after meals. Gut 6: 105–112Google Scholar
  5. 5.
    Connell AM (1968) In: Heider W, (ed) Handbook of physiology. Alimentary canal. IV. American Physiological Society, Washington DC, pp 2075–2091Google Scholar
  6. 6.
    Cornet A, Grivaux M (1969) Le sulpiride dans la maladie ulcéreuse. Sem Hop (Paris) 45: 840–861Google Scholar
  7. 7.
    Crismer R (1972) Les indications du sulpiride en thérapeutique gastroentérologique. Bruxelles-Méd 12: 866–870Google Scholar
  8. 8.
    Desruelles PJ (1972) Intérêt du sulpiride dans le traitement de certaines affections psychosomatiques. Lille Méd 17 [Suppl 1]: 41–43Google Scholar
  9. 9.
    Gullo L, Nesticò V, Ferrini L, Daniele C, Priori P, Muratori R, Labò G (1980) Stimulation of pancreatic secretion by sulpiride. Dig Dis Sci 25: 653–657Google Scholar
  10. 10.
    Harvey RF, Read AE (1973) Effect of cholecystokinin on colonic motility and symptoms in patients with the irritable bowel syndrome. Lancet 1: 1–3Google Scholar
  11. 11.
    Justine-Besançon L, Thominet M, Laville C, Magarit J (1967) Chemical constitution and biological properties of sulpiride. CR Acad Sci Paris 265: 1253–1254Google Scholar
  12. 12.
    Lam SK, Lai CL (1976) Inhibition of sulpiride on the cephalic phase of gastric acid and gastrin secretion in duodenal ulcer patients. Scand J Gastroenterol 11: 27–31Google Scholar
  13. 13.
    Lam SK, Lam KC, Lai CL, Yeung CK, Yam LYC, Wong WS (1979) Treatment of duodenal ulcer with antacid and sulpiride. A double-blind controlled study. Gastroenterology 76: 315–322Google Scholar
  14. 14.
    Lanfranchi GA, Marzio L, Cortini C, Moreno Osset E (1978) Motor effect of dopamine on human sigmoid colon: evidence for specific receptors. Dig Dis 23: 257–263Google Scholar
  15. 15.
    Lanfranchi GA, Marzio L, Cortini C, Trento L, Labò G (1978) In: Duthie HL (ed) Gastrointestinal motility in health and diseases. MTP Press, Lancaster, pp 161–171Google Scholar
  16. 16.
    Lechin F, Gomez F, Van Der Dijs B, Lechin E (1980) Distal colon motility in schizophrenic patients. J Clin Pharmacol 20: 459–464Google Scholar
  17. 17.
    Rattan S, Goyal RK (1976) Effect of dopamine on the esophageal smooth muscle in vivo. Gastroenterology 70: 377–381Google Scholar
  18. 18.
    Snape WJ Jr, Matarazzo SA, Cohen S (1978) Effect of eating and gastrointestinal hormones on human colonic myoelectric and motor activity. Gastroenterology 75: 373–378Google Scholar
  19. 19.
    Snape WJ Jr, Sun EA, Onyang A, Battle WM, Cohen S (1981) In: Basso N, Lezoche E, Speranza V, Walsh JM (eds) International symposium on brain-gut axis: The new frontier. Florence, June–July 1981, (abs.) p 167Google Scholar
  20. 20.
    Snape WJ Jr, Wright SH, Battle WM, Cohen S (1979) The gastrocolic response: evidence for a neural mechanism. Gastroenterology 77: 1235–1240Google Scholar
  21. 21.
    Spano PF, Trabucchi M, Corsini GV, Gessa GL (1979) Sulpiride and other benzamides. Raven Press, New YorkGoogle Scholar
  22. 22.
    Stadaas JO, Aune S (1972) The effect of sulpiride on gastric motility. Scand J Gastroenterol 7: 717–721Google Scholar
  23. 23.
    Sullivan MA, Cohen S, Snape WJ Jr (1978) Colonic myoelectrical activity in irritable bowel syndrome. N Engl J Med 298: 878–883Google Scholar
  24. 24.
    Thorner MO (1975) Dopamine is an important neurotransmitter in the autonomic nervous system. Lancet 1: 662–665Google Scholar
  25. 25.
    Valenzuela JE, Defilippi C, Diaz G, Merino Y (1979) Effect of dopamine on human gastric and pancreatic secretion. Gastroenterology 76: 323–326Google Scholar
  26. 26.
    Wiesel FA, Alfridsson G, Ehrnebo M, Sedvall G (1980) The pharmacokinetics of intravenous and oral sulpiride in healthy human subjects. Eur J Clin Pharmacol 17: 385–391Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • G. A. Lanfranchi
    • 1
  • G. Bazzocchi
    • 1
  • L. Marzio
    • 1
  • M. Campieri
    • 1
  • C. Brignola
    • 1
  1. 1.Istituto di Clinica Medica e Gastroenterologia dell'Università di BolognaBolognaItaly

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