European Journal of Clinical Pharmacology

, Volume 31, Issue 2, pp 253–254 | Cite as

Accidental overdose of pyrimethamine and sulphadoxine for malaria prophylaxis without adverse effects

  • A. Lindberg
  • Y. Bergqvist
  • L. Rombo
Letter To The Editors

Key words

pyrimethamine malaria sulphadoxine prophylaxis adverse effects overdose 


  1. 1.
    Bergqvist Y, Eriksson M (1985) Simultaneous determination of pyrimethamine and sulphadoxine in human plasma by highperformance liquid chromatography. Trans Roy Soc Trop Med Hyg 79: 279–301Google Scholar
  2. 2.
    Cavallito JC, Nichol CA, Brenckman WD Jr, De Angelis RL, Stickney DR, Simmons WS, Sigel CW (1978) Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog and man. Drug Metab Disp 6: 329–337Google Scholar
  3. 3.
    Stickney DR, Simmons WS, De Angelis RL, Rundles RW, Nichol CA (1973) Pharmacokinetics of pyrimethamine (PRM) and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DMP) relevant to meningeal leukemia. Proc Amer Ass Cancer Res 14: 52Google Scholar
  4. 4.
    Böhni E, Fast B, Rieder J, Schaerer K, Havas L (1969) Comparative toxicological, chemotherapeutic and pharmacokinetic studies with sulphormethoxine and other sulphonamides in animals and man. Chemotherapy 14: 195–226Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • A. Lindberg
    • 1
  • Y. Bergqvist
    • 2
  • L. Rombo
    • 3
  1. 1.Department of Infectious DiseasesHalmstad HospitalHalmstadSweden
  2. 2.Department of Clinical ChemistryFalu Central HospitalFalunSweden
  3. 3.Department of Infectious DiseasesRoslagstull Hospital, Karolinska InstituteStockholmSweden

Personalised recommendations