The pharmacokinetics of ofloxacin in healthy adult male volunteers

Conclusion

In healthy subjects ofloxacin pharmacokinetics were found to be linear in the dose range studied (100–400 mg). The terminal half-time was 7.5–8 h and plasma ofloxacin concentrations were still detectable at 16 and 24 h after administration. The ratio of renal ofloxacin clerance: creatinine clearance was 1.35–1.82 and was not significantly different for the three doses. The non-renal clearance of ofloxacin was 40–60 ml·min⁻¹, i.e. 20–30% of the total body clearance.

Food intake delayed the absorption of ofloxacin but did not significantly modify its elimination.