Summary
The concentrations of verapamil and norverapamil have been measured in milk and plasma samples from a 32year-old woman treated with verapamil 80 mg tds while breast-feeding her child.
The average steady-state concentrations of verapamil and norverapamil in milk were, respectively, 60% and 16% of the concentrations in plasma.
The breast-fed child received less than 0.01% of the dose of verapamil given to the mother. No verapamil or norverapamil (<1 ng/ml) could be detected in the plasma from the child.
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Anderson, P., Bondesson, U., Mattiasson, I. et al. Verapamil and norverapamil in plasma and breast milk during breast feeding. Eur J Clin Pharmacol 31, 625–627 (1987). https://doi.org/10.1007/BF00606644
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DOI: https://doi.org/10.1007/BF00606644