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The chronopharmacokinetics of indomethacin suppositories in healthy volunteers

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Summary

The pharmacokinetics of a single 100 mg indomethacin suppository were studied in 12 healthy volunteers on two occasions at least 7 days apart. Suppositories were administered in randomised order at 9.00 and 21.00 hours to see if there was evidence of a diurnal variation in kinetic parameters.

The study failed to show a significant change in single dose kinetics with the time of suppository administration. This is in contrast to previous work [1] demonstrating a circadian rhythm in the kinetics of a single oral dose of indomethacin. This suggests that the chronopharmacokinetics of indomethacin is dependent on the function of the upper gastrointestinal tract.

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Authors and Affiliations

  1. Department of Therapeutics and Pharmacology, The Queen's University of Belfast, Belfast, Northern Ireland

    A. J. Taggart & P. Passmore

  2. Department of Pharmacy, The Queen's University of Belfast, Belfast, Northern Ireland

    J. C. McElnay & B. Kerr

Authors
  1. A. J. Taggart
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  2. J. C. McElnay
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  3. B. Kerr
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  4. P. Passmore
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Taggart, A.J., McElnay, J.C., Kerr, B. et al. The chronopharmacokinetics of indomethacin suppositories in healthy volunteers. Eur J Clin Pharmacol 31, 617–619 (1987). https://doi.org/10.1007/BF00606642

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  • DOI: https://doi.org/10.1007/BF00606642

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