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The effect of propranolol on urinary prostaglandin E2 after frusemide administration in healthy subjects

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Summary

We have evaluated the effect of propranolol on urinary prostaglandin E2 (PGE2) excretion after frusemide administration in 8 healthy subjects. Urine was collected for 60 min after frusemide administration (20 mg intravenously) with or without propranolol pretreatment, and urinary excretion of PGE2, frusemide, and sodium were determined. Plasma renin activity (PRA) was also measured before and 60 min after frusemide administration.

Urinary PGE2 excretion after frusemide administration and frusemide-stimulated PRA were reduced after propranolol pretreatment. However, urine volume and the urinary excretion of frusemide and sodium were not influenced by propranolol pretreatment.

These results suggest that urinary PGE2 excretion after frusemide administration may be reduced by propranolol and that the mechanism responsible for the effect of proranolol on the frusemide-induced renal PGE2 production may be, at least in part, secondary to inhibition of the renin-angiotensin system.

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References

  1. Abe K, Irokawa N, Yasujima M, Seino M, Chiba S, Sakurai Y, Yoshinaga K, Saito T (1978) The kallikrein-kinin system and prostaglandins in the kidney: Their relation to furosemide-induced diuresis and to the renin-angiotensin-aldosterone system in man. Circ Res 43: 254–260

    Google Scholar 

  2. Attallah AA, Stahl RAK, Bloch DL, Lee JB (1979) Furosemide stimulates and saralasin inhibits renal prostaglandin E2 biosynthesis. Clin Res 27: 599 A

    Google Scholar 

  3. Attman PO, Aurell M, Johnsson G (1975) Effects of metoprolol and propranolol on frusemide-stimulated renin release in healthy subjects. Eur J Clin Pharmacol 8: 201–204

    Google Scholar 

  4. Berg KJ (1977) Acute effects of acetylsalicylic acid on renal function in normal man. Eur J Clin Pharmacol 11: 117–123

    Google Scholar 

  5. Brandt R, Seppälä E, Nowak J, Vapaatalo H (1984) Effect of propranolol, practolol and atenolol on human platelet thromboxane formation and plasma levels of prostaglandins 6-keto-F1α and E2. Prostaglandins Leukotrienes Med 16: 191–203

    Google Scholar 

  6. Frölich JC, Wilson TW, Sweetman BJ, Smigel M, Nies AS, Carr K, Watson JT, Oates JA (1975) Urinary prostaglandins: Identification and origin. J Clin Invest 55: 763–770

    Google Scholar 

  7. Graham RM, Campbell WB, Jackson EK (1982) Effects of short-term beta-blockade on blood pressure, plasma thromboxane B2, and plasma and urinary prostaglandin E2 and F2α in normal subjects. Clin Pharmacol Ther 31: 324–329

    Google Scholar 

  8. Ikeda I, Iinuma K, Takai M, Yanagawa Y, Kurata K, Ogihara T, Kumahara Y (1982) Measurement of plasma renin activity by a simple solid phase radioimmunoassay. J Clin Endocrinol Metab 54: 423–428

    Google Scholar 

  9. Jaffe BM, Behrman HR, Parker CW (1973) Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma. J Clin Invest 52: 398–405

    Google Scholar 

  10. Levenson DJ, Simmons CE Jr, Brenner BM (1982) Arachidonic acid metabolism, prostaglandins and the kidney. Am J Med 72: 354–374

    Google Scholar 

  11. Levine L, Moskowitz MA (1979) α- and β-adrenergic stimulation of arachidonic acid metabolism in cells in culture. Proc Natl Acad Sci USA 76: 6632–6636

    Google Scholar 

  12. MacDougall ML, Shoeman DW, Azarnoff DL (1975) Separation and quantitative analysis of furosemide and 4-chloro-5-sulfamoylanthranilic acid (CSA) by high pressure liquid chromatography. Res Commun Chem Pathol Pharmacol 10: 285–291

    Google Scholar 

  13. Mackay IG, Muir AL, Watson ML (1984) Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man. Br J Clin Pharmacol 17: 513–519

    Google Scholar 

  14. Odlind B, Beermann B (1980) Renal tubular secretion and effects of frusemide. Clin Pharmacol Ther 27: 784–790

    Google Scholar 

  15. Tiggeler RGWL, Koene RAP, Wijdeveld PGAB (1977) Inhibition of frusemide-induced natriuresis by indomethacin in patients with the nephrotic syndrome. Clin Sci Mol Med 52: 149–151

    Google Scholar 

  16. Vanderhoek JY, Feinstein MB (1979) Local anesthetics, chlorpromazine and propranolol inhibit stimulus-activation of phospholipase A2 in human platelets. Mol Pharmacol 16: 171–180

    Google Scholar 

  17. Weber PC, Scherer B, Larsson C (1977) Increase of free arachidonic acid by frusemide in man as the cause of prostaglandin and renin release. Eur J Pharmacol 41: 329–332

    Google Scholar 

  18. Wright JT Jr, Corder CN, Taylor R (1976) Studies on rat kidney 15-hydroxy-prostaglandin dehydrogenase. Bioch Pharmac 25: 1669–1673

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Oita National Medical School, Oita-gun, Oita, Japan

    A. Fujimura, H. Kajiyama & A. Ebihara

  2. Department of Medicine Section of Endocrinology, Metabolism and Hypertension, University of Oklahoma, 73126, Oklahoma City, OK, USA

    A. Fujimura

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  1. A. Fujimura
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  2. H. Kajiyama
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  3. A. Ebihara
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Fujimura, A., Kajiyama, H. & Ebihara, A. The effect of propranolol on urinary prostaglandin E2 after frusemide administration in healthy subjects. Eur J Clin Pharmacol 31, 605–607 (1987). https://doi.org/10.1007/BF00606639

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  • DOI: https://doi.org/10.1007/BF00606639

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