European Journal of Clinical Pharmacology

, Volume 22, Issue 1, pp 71–75 | Cite as

Pharmacokinetics of ceftriaxone following intravenous administration of a 3 g dose

  • P. J. McNamara
  • K. Stoeckel
  • W. H. Ziegler


The pharmacokinetic parameters of total (bound and unbound) and free (unbound) ceftriaxone in six healthy volunteers after intravenous injection of 39 were compared with low-dose data from a previous study. The dose-dependent behaviour of total drug was considerably more pronounced after the 3 gram dose. In contrast, total body clearance (Cl S F =258 ml/min), renal clearance (Cl R F =170 ml/min) and volume of distribution (V D(β) F =168 l) of free (unbound) drug did not differ from the data reported earlier. There was no significant change in biological half-life (t1/2(β)=7.8 h) or in the fraction excreted unchanged in urine (fu=0.67).

Key words

cephalosporin ceftriaxone protein binding non-linear pharmacokinetics intravenous injection plasma levels 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • P. J. McNamara
    • 1
  • K. Stoeckel
    • 1
  • W. H. Ziegler
    • 1
  1. 1.Biological Pharmaceutical Research DepartmentF. Hoffmann-La Roche & Co. Ltd.BaselSwitzerland

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