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Gastric emptying and absorption of acetylsalicylic acid administered as enteric-coated micro-granules

  • M. Alpsten
  • C. Bogentoft
  • G. Ekenved
  • L. Sölvell
Originals

Summary

Enteric-coated and uncoated microgranules of acetylsalicylic acid (ASA), labelled with51Cr, were administered orally to six healthy male volunteers in a cross-over study. Gastric emptying was studied using a profile scanning radiation technique. Absorption of ASA was followed by measuring the plasma concentration of salicylate. Gastric emptying both of uncoated and enteric-coated granules varied considerably between individuals, but in most cases was gradual and extended over a period of several hours. The median time until 50% and 90% were emptied from the stomach was 1 and 3–3.5 h, respectively, for both the uncoated and enteric-coated granules. The absorption of ASA from the uncoated granules occurred in parallel with the gastric emptying. However, with the enteric-coated granules, absorption was delayed for about 3 h after gastric emptying. It was concluded that the slow absorption of ASA from enteric-coated granules could be explained partly by gradual gastric emptying and partly by slow dissolution of the ASA granules in the intestine.

Key words

acetylsalicylic acid aspirin enteric-coating absorption gastric emptying 51Cr labelling gastric scanning 

References

  1. Alpsten M, Bogentoft C, Ekenved G, Sölvell L (1979) On the disintegration of hard gelatin capsules in fasting volunteers using a profile scanning technique. J Pharm Pharmacol 31: 480–481PubMedGoogle Scholar
  2. Blythe RH, Grass GM, MacDonnell DR (1959) The formulation and evaluation of enteric coated aspirin tablets. Am J Pharmacol 131: 206–216Google Scholar
  3. Bogentoft C, Carlsson I, Ekenved G, Magnusson A (1978) Influence of food on the absorption of acetylsalicylic acid from enteric-coated dosage forms. Eur J Clin Pharmacol 14: 351–355PubMedCrossRefGoogle Scholar
  4. Donaldson RM, Barreras RF (1966) Intestinal absorption of trace quantities of chromium. J Lab Clin Med 68: 484–493PubMedGoogle Scholar
  5. Leonards JR, Levy G (1965) Absorption and metabolism of aspirin administered in enteric-coated tablets. J Am Med Assoc 193: 99–104Google Scholar
  6. Merenda SJ, Green DM (1966) X-ray evaluation of tablet disintegration and gastric passage. Pharmacologist 8: 180Google Scholar
  7. Nimmo WS (1976) Drug, diseases and altered gastric emptying. Clin Pharmacokinet 1: 189–203PubMedGoogle Scholar
  8. Sköldborn H, Arvidsson B, Andersson M (1972) A new whole body monitoring laboratory. Acta Radiol (Suppl 313: 233–241CrossRefGoogle Scholar
  9. Wagner JG (1971) Enteric coatings. In: Biopharmaceutics and relevant pharmacokinetics. Drug Intelligence Publications, Hamilton Press, Hamilton Illinois, pp 158–165Google Scholar
  10. Wagner JG, Nelson E (1964) Kinetic analysis of blood levels and urinary excretion in the absorptive phase after single dose of drug. J Pharm Sci 53: 1392–1403PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • M. Alpsten
    • 1
  • C. Bogentoft
    • 2
  • G. Ekenved
    • 2
  • L. Sölvell
    • 3
  1. 1.Department of Radiation PhysicsUniversity of GothenburgGothenburgSweden
  2. 2.Research LaboratoriesAB HässleMölndalSweden
  3. 3.Department of Internal MedicineMölndal HospitalMölndalSweden

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