European Journal of Clinical Pharmacology

, Volume 11, Issue 3, pp 199–201 | Cite as

Clozapine-induced agranulocytosis: A situation report up to August 1976

  • B. Anderman
  • R. W. Griffith


The frequency of agranulocytosis in association with clozapine therapy has been estimated and compared with data reported for phenothiazine-induced agranulocytosis. Apart from the “epidemic” in Finland, where the frequency was 21 times that in other countries, there is no evidence that clozapine-related agranulocytosis is more common than the phenothiazine-related disorder. Furthermore, results are given to show that strict adherence to precautionary measures (e.g. weekly blood counts) reduces the mortality-rate of this condition.

Key words

Agranulocytosis granulocytopenia Leponex® clozapine neuroleptic phenothiazine 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Amsler, H. A., Teerenhovi, L., Barth, E., Harjula, K.: Granulocytopenia in patients treated with clozapine. (manuscript in preparation)Google Scholar
  2. 2.
    Ayd, F. J., Jr.: Chlorpromazine: Ten years' experience. J. Amer. med. Ass.184, 51–54 (1963)Google Scholar
  3. 3.
    Fiore, J. M., Noonan, F. M.: Agranulocytosis due to mepazine (phenothiazine). J. Med.260, 375–378 (1959)Google Scholar
  4. 4.
    Giacobini, A. E., Lassenius, B.: Clorpromazinbehandling. Nordisk Med.52, 1693–1699 (1954)Google Scholar
  5. 5.
    Goldman, D.: Agranulocytosis associated with administration of chlorpromazine. Arch. intern. Med.96, 496–499 (1955)Google Scholar
  6. 6.
    Griffith, R. W., Saameli, K.: Clozapine and agranulocytosis. Lancet1975 II, 657Google Scholar
  7. 7.
    Hippius, H., Kanig, K.: Die Agranulocytose unter neuropsychiatrischer Phenothiazin-Therapie. Ärztl. Wschr.13, 501–507 (1958)Google Scholar
  8. 8.
    Hollister, L. E.: Complications from psychotherapeutic drugs — 1964. Clin. Pharmacol. Ther.5, 322–333 (1964)Google Scholar
  9. 9.
    Hollister, L. E.: Adverse reactions to phenothiazines. J. Amer. med. Ass.189, 311–313 (1964)Google Scholar
  10. 10.
    Idänpään-Heikkilä, J., Alhava, E., Olkinuora, M., Palva, I.: Clozapine and agranulocytosis. Lancet1975 II, 611Google Scholar
  11. 11.
    Litvak, R., Kaelbling, R.: Agranulocytosis, leukopenia, and psychotropic drugs. Arch. gen. Psychiat.24, 265–267 (1971)Google Scholar
  12. 12.
    Pisciotta, A. V.: Agranulocytosis induced by certain phenothiazine derivates. J. Amer. med. Ass.208, 1862–1868 (1969)Google Scholar
  13. 13.
    Pisciotta, A. V.: Immune and toxic mechanisms in drug-induced agranulocytosis. Semin. Hematol.10, 279–310 (1973)Google Scholar
  14. 14.
    Pollack, B.: Preliminary report on 500 patients treated with thorazine at Rochester State Hospital. Psychiat. Quart.29, 439–456 (1955)Google Scholar
  15. 15.
    Raskin, N.: Agranulocytosis in patients treated with Thorazine. Amer. J. Psychiat.113, 991–992 (1957)Google Scholar
  16. 16.
    Tuteur, W.: A case of fatal agranulocytosis due to chlorpromazine. Amer. J. Psychiat.113, 76 (1956)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • B. Anderman
    • 1
  • R. W. Griffith
    • 1
  1. 1.Biological and Medical ResearchSandoz Ltd.BasleSwitzerland

Personalised recommendations