European Journal of Clinical Pharmacology

, Volume 11, Issue 3, pp 199–201 | Cite as

Clozapine-induced agranulocytosis: A situation report up to August 1976

  • B. Anderman
  • R. W. Griffith
Originals

Summary

The frequency of agranulocytosis in association with clozapine therapy has been estimated and compared with data reported for phenothiazine-induced agranulocytosis. Apart from the “epidemic” in Finland, where the frequency was 21 times that in other countries, there is no evidence that clozapine-related agranulocytosis is more common than the phenothiazine-related disorder. Furthermore, results are given to show that strict adherence to precautionary measures (e.g. weekly blood counts) reduces the mortality-rate of this condition.

Key words

Agranulocytosis granulocytopenia Leponex® clozapine neuroleptic phenothiazine 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • B. Anderman
    • 1
  • R. W. Griffith
    • 1
  1. 1.Biological and Medical ResearchSandoz Ltd.BasleSwitzerland

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