European Journal of Clinical Pharmacology

, Volume 23, Issue 5, pp 423–427 | Cite as

Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time

  • E. Tremoli
  • L. Bertoli
  • R. Merlini
  • S. Colli
  • P. Maderna
  • O. Mantero
  • C. R. Sirtori


The platelet regeneration time (PRT) determined in a group of hypoxaemic patients with chronic obstructive airways disease (COAD), before and after treatment with dipyridamole 150 mg tid, was compared with a group of control subjects. The PRT was computed by a modified non-radioisotope technique and was expressed as t1/2 in days. The patient group showed a significantly shortened PRT as compared to controls of the same age and sex (2.10±0.16 vs 3.65±0.26 days;p<0.001). One month of dipyridamole administration resulted in prolongation of the PRT in COAD patients (2.10±0.16 days pre-treatment vs 2.75±0.20 post-treatment;p<0.01), without affecting the platelet cyclo-oxygenase system. This study indicates that dipyridamole may be beneficial in pathological conditions, which are characterized by increased platelet turnover, possibly leading to frequent thromboembolic complications.

Key words

chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • E. Tremoli
    • 1
  • L. Bertoli
    • 2
  • R. Merlini
    • 2
  • S. Colli
    • 1
  • P. Maderna
    • 1
  • O. Mantero
    • 2
  • C. R. Sirtori
    • 1
  1. 1.E. Grossi Paoletti CentreUniversity of MilanMilanItaly
  2. 2.Vergani DivisionHospital of NiguardaMilanItaly

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