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European Journal of Clinical Pharmacology

, Volume 16, Issue 5, pp 327–330 | Cite as

Food-induced reduction in bioavailability of atenolol

  • A. Melander
  • P. Stenberg
  • H. Liedholm
  • B. Scherstén
  • E. Wåhlin-Boll
Originals

Summary

The influence of food intake on the bioavailability of the beta-adrenoceptor blocker atenolol was assessed by measurement of its single-dose kinetics in ten healthy volunteers, who took 100 mg both in the fasting state and together with a standardized breakfast. Food intake significantly shortened the time to reach peak concentration (2.7 h vs 1.5 h), but caused a significant reduction in AUC values, the mean decrease being 20%. The elimination half-life was unaffected. Atenolol, which is relatively hydrophilic, is incompletely absorbed in the fasting state, and escapes first-pass metabolism. The present findings indicate that food intake causes further impairment of its absorption, even though the absorption rate may initially be enhanced. This contrasts with previous observations on the more lipophilic beta-adrenoceptor blockers propranolol and metoprolol.

Key words

atenolol food intake pharmacokinetics 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • A. Melander
    • 1
    • 2
  • P. Stenberg
    • 1
    • 2
  • H. Liedholm
    • 1
    • 2
  • B. Scherstén
    • 1
    • 2
  • E. Wåhlin-Boll
    • 1
    • 2
  1. 1.Departments of Clinical Pharmacology (Malmö General Hospital) and Medicine (Lund University Hospital)University of Lund, Pharmacy of Malmö General HospitalSweden
  2. 2.Department of Community Care SciencesDalbySweden

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