European Journal of Clinical Pharmacology

, Volume 16, Issue 5, pp 319–322 | Cite as

Multicentre comparative trial of tienilic acid and hydrochlorothiazide in hypertensive patients

  • C. Ponticelli
  • A. Lechi
  • T. di Perri
  • B. Redaelli
  • F. Locatelli
  • E. Rivolta
  • G. Covi
  • G. L. Messa
  • G. Pincella
  • L. Pedrini
  • M. Recchia
  • P. Gouère
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  • 16 Downloads

Summary

To compare the clinical and metabolic effects of a new diuretic uricosuric agent, tienilic acid, with those of hydrochlorothiazide, a multicentre double-blind trial was performed in 56 hypertensive patients. Twenty — eight patients were randomly assigned to take tienilic acid and 28 to take hydrochlorothiazide. The diuretic and anti-hypertensive actions of the two compounds were similar. No significant differences were observed between tienilic acid and hydrochlorothiazide in their effects on urinary and serum electrolytes, hepatic and renal function tests, and fasting lipids. The patients who received tienilic acid showed a significant fall in serum uric acid, mediated by the uricosuric effect. The availability of an agent combining diuretic, anti-hypertensive and hypouricemic effects offers promise in the treatment of arterial hypertension.

Key words

tientilic acid hydrochlorothiazide hypertension diuretics hyperuricemia hypouricemic drugs 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • C. Ponticelli
    • 1
  • A. Lechi
    • 2
  • T. di Perri
    • 3
  • B. Redaelli
    • 4
  • F. Locatelli
    • 5
  • E. Rivolta
    • 1
  • G. Covi
    • 2
  • G. L. Messa
    • 3
  • G. Pincella
    • 4
  • L. Pedrini
    • 5
  • M. Recchia
    • 6
  • P. Gouère
    • 7
  1. 1.Divisione di Nefrologia e DialisiOspedale Policlinico di MilanoItaly
  2. 2.Sede staccata di Verona, Istituto di Clinica MedicaUniversità di PadovaItaly
  3. 3.Istituto di Patologia MedicaUniversità di SienaItaly
  4. 4.Divisione di Nefrologia e DialisiOspedale di MonzaItaly
  5. 5.Divisione di Nefrologia e DialisiOspedale di LeccoItaly
  6. 6.Biostatistic UnitIstituto Mario NegriMilanoItaly
  7. 7.CREPHAR, Centre de Recherche et Pharmacologie, Albert Rolland Chilly MazarinFrance

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