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Das Pigmentierte Xerodermoid

Ein Defekt der Rekombinations-Erholung von UV-Schäden

Pigmented Xerodermoid

A Defect of Recombinational Recovery after UV Induced Damages

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Summary

Pigmented Xerodermoid is a skin disease similar to Xeroderma pigmentosum. In both traits the skin has an increased light sensitivity and the lymphocytes show a decreased survival rate after UV irradiation. In Xeroderma pigmentosum a defect of endonuclease in the excision repair system can be demonstrated, while in pigmented Xerodermoid the defect seems to be located in the recovery process during recombination. In normal human epidermal cells one can imitate a similar effect by coffein, a substance influencing recombination.

Zusammenfassung

Das pigmentierte Xerodermoid ist eine dem Xeroderma pigmentosum sehr ähnliche Hautkrankheit. Bei beiden ist die Haut verstärkt lichtempfindlich und es besteht auch eine verminderte Überlebensrate von UV bestrahlten Lymphocyten. Während beim Xeroderma pigmentosum ein Mangel der UV spezifischen Endonuclease des Excisionsrepair-Systems vorliegt, scheint der Defekt beim pigmentierten Xerodermoid im Ablauf derjenigen Erholungsvorgänge zu liegen, die sich bei der Rekombination auswirken. Bei gesunden menschlichen Epidermiszellen kann ein gleichsinniger Effekt durch Coffein erreicht werden; eine Substanz, von der man weiß, daß sie die Rekombination hemmt.

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Authors and Affiliations

  1. Universitäts-Hautklinik Heidelberg, Germany

    Ernst G. Jung

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  1. Ernst G. Jung
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Jung, E.G. Das Pigmentierte Xerodermoid. Arch. Derm. Forsch. 241, 33–43 (1971). https://doi.org/10.1007/BF00604134

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  • DOI: https://doi.org/10.1007/BF00604134

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