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Gaschromatographische Untersuchungen der Talgdrüsenlipide

II. Zusammensetzung der Talgdrüsenlipide im Altersablauf

Analysis of sebaceous glands lipids by gas-chromatography

II. Composition of Sebaceous Gland Lipids in Different Age Groups

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Summary

In a total of 9,500 human sebaceous glands isolated by the method of Kellum (1966) a quantitative analysis of the esterified triglyceride- and wax ester-fatty acids, of sequalene, cholesterol and phospholipids was performed according to age groups.

Serveral peaks for triglyceride- and wax ester-fatty acids were found. Highest values for phospholipids were observed in the early age group, whereas squalene showed a maximum in the very old age group.

The values for sebaceous gland cholesterol increased up to an average age of 44.5 years, were reduced in the following age groups but showed a second peak in old persons (> 80 years). For all components except phospholipids highest values were observed in the old age group.

The results are discussed especially in relation to the Kellum method of sampling the glands. It is suggested that between the 70th and 80th year of age the composition of the secretory product becomes profoundly changed.

Zusammenfassung

Nach der von Kellum (1966) beschriebenen Methode wurden 9500 Talgdrüsen postmortal isoliert. Die in Triglyceriden und Wachsestern gebundenen Fettsäuren, Squalen, Cholesterin und Phospholipoide im Altersablauf wurden quantitativ bestimmt.

Die Ergebnisse zeigten, daß für die in Triglyceriden und Wachsestern gebundenen Fettsäuren mehrere Maxima existieren.

Bei den Phospholipoiden trat ein eindrucksvoller Altersgipfel bei der jüngsten und für Squalen bei der höchsten Altersgruppe auf.

Der Cholesteringehalt nahm bis zu einem Durchschnittsalter von 44,5 Jahren zu, fiel dann ab und erreichte bei alten Personen (> 80 Jahre) ein erneutes Maximum.

Am eindrucksvollsten war, mit Ausnahme der Phospholipoide, der Altersgipfel aller Komponenten in der höchsten Altersgruppe.

Die biologischen Resultate werden diskutiert und die Problematik der Kellumschen Isolierungsmethode wird aufgezeigt.

Es hat sich der Verdacht verstärkt, daß zwischen dem 70. und 80. Lebensjahr die Zusammensetzung des Talgdrüsensekrets eine entscheidende Veränderung erfährt.

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Literatur

  • Boughton, B., Mackenna, R. M. B., Wheatley, V. R., Wormall, A.: Studies of sebum 8. Observations on the squalene and cholesterol content and the possible function of squalene in human sebum. Biochem. J.66, 32–38 (1957).

    Google Scholar 

  • —, Wheatley, V. R.: The fatty acid composition of the skin surface fat (“sebum”) of normal human subjects. J. invest. Derm.33, 49–55 (1959).

    Google Scholar 

  • Haahti, E.: Major lipid constituents of human skin surface with special reference to gas chromatographic methods. Scand. J. clin. Lab. Invest.13, Suppl. 59 (1961).

    Google Scholar 

  • Kellum, R. E.: Isolation of human sebaceous glands. Arch. Derm.93, 610 (1966).

    Google Scholar 

  • Kirk, E.: Quantitative determination of the skin lipid secretion in middle-aged and old individuals. J. Geront.3, 251–266 (1948).

    Google Scholar 

  • Kvorning, S. A.: Investigations into the Pharmacology of the skin fats and ointments. IV. Investigation into the composition of the lipids of the skin of normal individuals. Acta pharmacol. (Kbh.)5, 383–396 (1949).

    Google Scholar 

  • Lincke, H.: Beiträge zur Chemie des Hautfettes. III. Der Talg-Cholesterinspiegel. Arch. Derm.195, 540–548 (1953).

    Google Scholar 

  • Nicolaides, N., Foster, R. C.: Esters in human hair fat. J. Amer. Oil Chemist's Soc.33, 404–409 (1956).

    Google Scholar 

  • Peter, G., Schröpl, F., Lippross, R., Weiss, G.: Gaschromatographische Untersuchungen der Talgdrüsenlipide. I. Bestimmung der Gesamtlipide. Arch. klin. exp. Derm.239, 12–21 (1970).

    Google Scholar 

  • Rothman, S.: Physiology and Biochemistry of the skin. Composition of the lipid surface film. Chicago: University of Chicago Press 1954.

    Google Scholar 

  • Rust, S., Harth, P., Herrmann, F.: Untersuchung der freien Fettsäuren im Hautoberflächenfett von Hautgesunden. Arch. klin. exp. Derm.231, 300–310 (1968).

    Google Scholar 

  • Stüttgen, G., Vogelberg, K. H.: Die Lipide der Hautxanthome. Arch. klin. exp. Derm.222, 43–56 (1965).

    Google Scholar 

  • Wheatley, V. R.: Biochemistry of sebum. J. Soc. Cosm. Chem.10, 206–214 (1959).

    Google Scholar 

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Authors and Affiliations

  1. Biochemische Abteilung der Dermatologischen Klinik und Poliklinik, Universität Würzburg, Germany

    G. Peter, W. Ritter, F. Schröpl & R. Peter

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  1. G. Peter
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  2. W. Ritter
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  3. F. Schröpl
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  4. R. Peter
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Peter, G., Ritter, W., Schröpl, F. et al. Gaschromatographische Untersuchungen der Talgdrüsenlipide. Arch. Derm. Forsch. 241, 22–32 (1971). https://doi.org/10.1007/BF00604133

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  • DOI: https://doi.org/10.1007/BF00604133

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