Summary
Voltage noise spectra of the node of Ranvier upon depolarization were investigated in normal Ringer solution and in TTX, DNP, TEA and saccharose Ringer. The intensities of both the 1/f component and the shot effect component of the voltage noise did change in TEA Ringer only. This excludes the sodium channels and active transport as sources of these noises. From considerations of a representation of the potassium and leakage system it follows that leakage as the sole noise source is excluded. The shot effect noise is probably caused by fluctuations of the potassium conductance. For the 1/f noise the behaviour is more complex. Part of it however is due to the potassium system.
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This work was supported by a grant from the Netherlands Organization for Pure Research (Z.W.O.)
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Siebenga, E., de Goede, J. & Verveen, A.A. The influence of TTX, DNP and TEA on membrane flicker noise and shot effect noise of the frog node of Ranvier. Pflugers Arch. 351, 25–34 (1974). https://doi.org/10.1007/BF00603508
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DOI: https://doi.org/10.1007/BF00603508