Summary
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1.
Blood-lymph permeability increasing effects of frog liver lysosomes,Escherichia coli 0111 endotoxin, bradykinin and serotonin were demonstrated in frogs with a method developed by the authors. These actions were expressed in a faster dye saturation in the lymph as compared to that of the controls.
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2.
The method is based on the determinations of concentration of Evans blue transported as protein-bound dye into the lymph.
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3.
Frog liver and polymorphonuclear leukocyte lysosomes had a capillary permeability increasing action tested by local skin response when injecting Evans blue intravenously in mice.
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4.
All these phenomena are similar to events described earlier in mammalian systems.
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Csákó, G., Reichel, A., Csernyánszky, H. et al. Effect of various lysosomes and endotoxin on vascular permeability in frogs and mice. Pflugers Arch. 353, 151–157 (1975). https://doi.org/10.1007/BF00599875
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DOI: https://doi.org/10.1007/BF00599875