, Volume 34, Issue 6, pp 517–519 | Cite as

Effects of radiotherapy determined by11C-methyl-l-methionine positron emission tomography in patients with primary cerebral malignant lymphoma

  • J. Sawataishi
  • K. Mineura
  • T. Sasajima
  • M. Kowada
  • A. Sugawara
  • F. Shishido
Diagnostic Neuroradiology


Two cases of histologically proven primary cerebral malignant lymphoma were examined serially with positron emission tomography (PET) using11C-methyl-l-methionine (11C Met). Lesions delineated by11C Met accumulation extended beyond enhancing areas on either X-ray computed tomography (CT) or magnetic resonance imaging. High uptake of11C Met accurately showed biologically active and residual tumours, at a time when disappearance of a contrast-enhancing lesion on CT seemed to indicate involution. PET provides valuable information on the extent of tumour and assessment of radiotherapy in malignant lymphoma.

Key words

Cerebral malignant lymphoma 11C-methyl-l-methionine Positron emission tomography Radiotherapy 


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  1. 1.
    Mineura K, Sasajima T, Suda Y, Kowada M, Shishido F, Uemura K (1989) Early and accurate detection of primary cerebral glioma with interfibrillary growth using11C-l-methionine positron emmission tomography. J Med Imaging 33:192–196Google Scholar
  2. 2.
    Derlon JM, Bourdet C, Bustany P, Chatel M, Theron J, Darcel F, Syrota A (1989) [11C]l-methionine uptake in gliomas. Neurosurgery 25:720–728Google Scholar
  3. 3.
    Erickson K, Lilja A, Bergstrom M, Collins P, Eriksson L, Ehrin E, Holst H von, Lundqvist H, Langstrom B, Mosskin M (1985) Positron emission tomography with ([11C]methyl)-l-methionine, [11C]d-glucose, and [68Ga]EDTA in supratentorial tumors. J Comput Assist Tomogr 9:683–689Google Scholar
  4. 4.
    Hochberg FH, Millar DC (1988) Primary central nervous system lymphoma. J Neurosurg 68:835–853Google Scholar
  5. 5.
    Jiddane M, Nicoli F, Diaz P, Bergvall U, Vincentell F, Hassoun J, Salamon G (1986) Intracranial malignant lymphoma. J Neurosurg 65:592–599Google Scholar
  6. 6.
    Mendenhall NP, Thar TL, Agee OF, Harty-Golder B, Ballinger WE, Millon RR (1983) Primary lymphoma of the central nervous system: computerized tomography scan characteristics and treatment results for 12 cases. Cancer 52:1993–2000Google Scholar
  7. 7.
    Murray K, Kin L, Cox J (1986) Primary lymphoma of the central nervous system: results of treatment of 11 cases and review of the literature. J Neurosurg 65:600–607Google Scholar
  8. 8.
    Grant JW, Gallagher PJ, Jones DB (1986) Primary cerebral lymphoma: a histologic and immunohistochemical study of six cases. Arch Pathol Lab Med 110:897–901Google Scholar
  9. 9.
    Newell GR, Cabanillas FG, Hagemeister FJ, Butler JJ (1987) Incidence of lymphoma in the US classified by the Working Formulation. Cancer 59:857–861Google Scholar
  10. 10.
    Baumgartner JE, Rachlin JR, Beckstead JH, Meeker TC, Levy RM, Wara WM, Rosenblum ML (1990) Primary central nervous system lymphomas: natural history and response to radiation therapy in 55 patients with acquired immunodeficiency syndrome. J Neurosurg 73:206–211Google Scholar
  11. 11.
    Leibel SA, Sheline GE (1987) Radiation therapy for neoplasms of the brain. J Neurosurg 66:1–22Google Scholar
  12. 12.
    Niibe H, Tamaki Y, Watanabe S, Masaki N, Horiuchi J, Hayabuchi N, Kaneda K, Morita K (1988) Therapeutic results of primary cerebral malignant lymphoma of the brain (in Japanese). Jpn J Cancer Clin 34:651–667Google Scholar
  13. 13.
    Kuwabara Y, Ichiya Y, Otsuka M, Miyake Y, Gunasekawa R, Hasuo K, Masuda K, Takeshita I, Fukui H (1988) High [18F]FDG uptake in primary cerebral lymphoma: a PET study. J Comput Assist Tomogr 12:47–48Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • J. Sawataishi
    • 1
  • K. Mineura
    • 1
  • T. Sasajima
    • 1
  • M. Kowada
    • 1
  • A. Sugawara
    • 2
  • F. Shishido
    • 3
  1. 1.Neurosurgical ServiceAkita University HospitalAkitaJapan
  2. 2.Department of NeurosurgeryNakadori HospitalAkitaJapan
  3. 3.Department of Radiology and Nuclear MedicineResearch Institute for Brain and Blood Vessels-AkitaAkitaJapan

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