Summary
The ability to visualise multiple selerosis lesions in vivo with magnetic resonance imaging suggests and important role in monitoring the course of the disease. In order to help the long-term assessment of prospective treatments, a semi-automated technique for measuring lesion volume has been developed to provide a quantitative index of disease progression. Results are presented from a preliminary study with a single patient and compared to measurements taken from lesion outlines traced by a neuroradiologist, two neurologists and a technician. The semi-automated technique achieved a precision of 6% compared to a range of 12–33% for the manual tracing method. It also reduced the human interaction time from at least 60 min to 15 min.
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Noseworthy JH, Van der Voort MK, Wong CJ, Ebers GC (1990) Interrater variability with the expanded disability status scale (EDSS) and functional systems (FS) in a multiple sclerosis clinical trial. Neurology 40: 971–975
Young IR, Hall AS, Pallis CA, Legg NJ, Bydder GM, Steiner RE (1981) Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet II: 1063–1066
Ormerod IEC, Miller DH, McDonald WI, du Boulay EPGH, Rudge P, Kendall BE, Moseley IF, Johnson G, Tofts PS, Halliday AM, Bronstein AM, Scaravilli F, Harding AE, Barnes D, Zilkha KJ (1987) The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions: a quantitative study. Brain 110: 1579–1616
Isaac C, Genton M, Jardre C, Grochowski E, Palner M, Kastrukoff LF, Oger J, Paty DW (1988) Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology 38: 1511–1515
Kennedy DN, Filipek PA, Caviness VS (1989) Anatomic segmentation and volumetric calculations in nuclear magnetic resonance imaging. IEEE Trans Med Imaging 8: 1–7
Jack CR, Gehring DG, Sharbrough FW, Felmlee JP, Forbes G, Hench VS, Zinsmeister AR (1988) Temporal lobe volume measurement from MR images: accuracy and left-right asymmetry in normal persons. J Comput Assist Tomogr 12: 21–29
Lim KO, Pfefferbaum A (1989) Segmentation of MR brain images into cerebrospinal fluid spaces, white and grey matter. J Comput Assist Tomogr 13:588–593
Cline HE, Lorensen WE, Kikinis R, Jolesz F (1990) Three-dimensional segmentation of MR images of the head using probability and connectivity. J Comput Assist Tomogr 14: 1037–1045
Mac Manus DG, Kermode AG, Tofts PS (1989) A repositioning technique for cerebral magnetic resonance imaging of patients with multiple sclerosis. Abstracts of the SMRM 8: 617
Wicks DAG, Barker GJ, Tofts PS (1991) Correction of intensity nonuniformity in MR images of any orientation. Magn Reson Imaging
Larsson HBW, Frederiksen J, Kjaer L, Hendriksen O, Olesen J (1988) In vivo determination of T1 and T2 on the brain of patients with severe but stable multiple sclerosis. Magn Reson Med 7: 43–55
Bland JM, Altman DG (1986) Statistical methods of assessing agreement between two methods of clinical measurement. Lancet I: 307–310
British Standards Institution (1979) Precision of test methods. I. Guide for the determination and reproducibility for a standard test method. British Standard 5497
Thompson AJ, Miller D, Youl B, Mac Manus D, Moore S, Kingsley D, Kendall B, Feinstein A, McDonald WI (1992) Serial gadolinium enhanced MRI in relapsing remitting multiple sclerosis of varying disease duration. Neurology (in press)
Brownell B, Hughes JT (1962) The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry 25: 315–320
Lumsden CE (1970) The neuropathology of multiple sclerosis. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 9. North Holland Amsterdam, pp 217–309
Miller DH, Barkhof F, Berry I, Kappos L, Scotti G, Thompson AJ (1991) Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. J Neurol Neurosurg Psychiatry 54: 683–688
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Wicks, D.A.G., Tofts, P.S., Miller, D.H. et al. Volume measurement of multiple sclerosis lesions with magnetic resonance images. Neuroradiology 34, 475–479 (1992). https://doi.org/10.1007/BF00598953
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DOI: https://doi.org/10.1007/BF00598953