The correlation of magnetic resonance imaging (MRI) with histopathological findings was analysed in 26 patients with untreated cerebral gliomas. In low-grade gliomas, T2-weighted images demonstrated relatively homogeneous high-intensity lesions involving both the grey and the white matter. In high-grade gliomas, especially grade IV, T2-weighted images demonstrated prominent heterogeneity in signal intensity, which consisted of a hyperintense “core”, less hyperintense or normal intensity “rim” and surrounding finger-like areas of high intensity. Marked and irregular contrast enhancement was evident in all but one case of these high-grade gliomas in which gadolinium-DTPA was used. Histological examination revealed tumour cells extending as far as the borders of the high-intensity areas shown on T2-weighted images in both high-and low-grade gliomas, but in 5 of 8 low-grade and 4 of 18 high-grade gliomas, isolated tumour cells extended beyond the hyperintense areas shown on T2-weighted images.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
Tax calculation will be finalised during checkout.
Berry I, Brant-Zawadzki M, Osaki L, Brasch R, Murovic J, Newton TH (1986) Gd-DTPA in clinical MR of the brain. 2. Extraaxial lesions and normal structures. AJNR 7:789–793
Brant-Zawadzki M, Badami JP, Mills CM, Norman D, Newton TH (1984) Primary intracranial tumor imaging: a comparison of magnetic resonance and CT. Radiology 150:435–440
Brant-Zawadzki M, Berry I, Osaki L, Brasch R, Murovic J, Norman D (1986) Gd-DTPA in clinical MR of the brain. 1. Intraaxial lesions. AJNR 7: 781–788
Buonnano FS, Pykett IL, Brady TJ, Black P, New PFJ, Richardson EP, Hinshaw WS Jr, Goldman M, Pohost G, Kistler, JP (1982) Clinical relevance of two different nuclear magnetic (NMR) approaches to imaging of a low grade astrocytoma. J Comput Assist Tomogr 6:529–535
Bydder GM, Steiner RE, Young IR, Hall AS, Thomas DJ, Marshall J, Pallis CA, Legg NJ (1982). Clinical NMR imaging of the brain: 140 cases. AJR 139:215–236
Just M, Thelen M (1988) Tissue characterization with T1, T2, and proton density values: results in 160 patients with brain tumors. Radiology 169:779–785
Lee BCP, Kneeland JB, Cahill PT, Deck MDF (1985) MR recognition of supratentorial tumors. AJNR 6:871–878
Kelly PJ, Daumas-Duport C, Scheithauer BW, Kall BA, Kispert DB (1987) Stereotaxic histologic correlations of computed tomography-and magnetic resonance imaging-defined abnormalities in patients with glial neoplasms. Mayo Clin Proc 62:450–459
Araki T, Inoue T, Suzuki H, Machida T, Iio M (1984) Magnetic resonance imaging ot the brain tumors: measurement of T1. Radiology 150:95–98
Dean BL, Drayer BP, Bird CR, Flom RA, Hodak JA, Coons SW, Carey RG (1990) Gliomas: classification with MR imaging. Radiology 174:411–415
Jackson JA, Derman HS, Harper RI, Willcott MR, Ford JJ, Schneiders NJ, McCrary JA, Kelly A, Brayan RN (1984) Nuclear magnetic resonance diagnosis of an anaplastic astrocytoma. Magn Reson Imaging 2:227–233
Kelly PJ, Daumas-Duport C, Kispert DB, Kall BA, Scheithauer BW, Illig JJ (1987) Imaging-based stereotaxic serial biopsies in untreated intracranial neoplasms. J Neurosurg 66:865–874
Laster DW, Ball MP, Moody DM, Witcofski RL, Kelly DL Jr (1984) Results of nuclear magnetic resonance with cerebral glioma. Comparison with computed tomography. Surg Neurol 22: 113–122
Le Bas JF, Leviel JL, Decorps M, Benabid AL (1984) NMR relaxation times from serial sterotaxic biopsies in human brain tumors. J Comput Assist Tomogr 6:1048–1057
Price AC, Runge VM, Allen JH, Partain CL, James AE (1986) Primary glioma: diagnosis with magnetic resonance imaging. J Comput Tomogr 10:325–334
Burger PC, Heinz ER, Shibata T, Kleihues P (1988) Topographic anatomy and CT correlations in the untreated glioblastoma multiforme. J Neurosurg 68:698–704
Cope FW (1969) Nuclear magnetic resonance evidence using D2O for structured water in muscle and brain. Biophys J 9:303–319
Hazlewood CF, Nichols BL, Chamberlain NF (1969) Evidence for the existence of a minimum of two phases of ordered water in skeletal muscle. Nature 222:747–750
Kiricuta IC Jr., Simplaceanu V (1975) Tissue water content and nuclear magnetic resonance in normal and tumor tissues. Cancer Res 35:1164–1167
Smith AS, Weinstein MA, Modic MT, Pavlicek W, Rogers LR Budd TG, Bukowski RM, Purvis JD, Weick JK, Dechesneau PM (1985) Magnetic resonance with marked T2-weighted images: improved demonstration of brain lesions, tumor, and edema. AJNR 6:691–697
Hollis DP, Economou JS, Parks LC, Eggleston JC, Saryan LA, Czeisler JL (1973) Nuclear magnetic resonance studies of several experimental and human malignant tumors. Cancer Res 33: 2156–2160
Komiyama M, Yagura H, Baba M, Yasui T, Hakuba A, Nishimura S, Inoue Y (1987) Possibility of tissue characterization of brain tumors using T1 and T2 values. AJNR 8:65–70
Whelan HT, Clanton JA, Moore PM, Tolner DJ, Kessler RM, Whetsell WO (1987) Magnetic resonance brain tumor imaging in canine glioma. Neurology 37:1235–1239
Doom GC, Hecht S, Brant-Zawadzki M, Berthiaume Y, Norman D, Newton TH (1986) Brain radiation lesions: MR imaging. Radiology 158:149–155
Tanaka C, Naruse S, Horiguchi Y, Higuchi T, Ebisu T, Hirakawa K, Maki S, Ohno Y (1987) Magnetic resonance imaging of experimental brain edema (in Japanese). Prog Comput Tomogr 9: 181–187
Parizel PM, Degryse HR, Gheuens J, Martin JJ, Vyve MV, Porte CDL, Selosse P, Heyning VDP, Schepper AMD, (1989) Gadolinium-DOTA enhanced MR imaging of intracranial lesions. J Comput Assist Tomogr 13:378–385
Claussen C, Laniado M, Schorner W, Niendorf HP, Weinmann HJ, Fiegler W, Felix R (1985) Gadolinium-DTPA in MR imaging of glioblastomas and intracranial metastases. AJNR 6:669–674
Turski PA, Houston LW, Perman WH, Hald JK, Turski D, Strother CM, Sackett JF (1987) Experimental and human brain neoplasms: detection with in vivo sodium MR imaging. Radiology 163:245–249
Runge VM, Price AC, Wehr CJ, Atokinson JB, Tweedle MF (1985) Contrast enhanced MRI: evaluation of a canine model of osmotic blood-brain barrier disruption. Invest Radiol 20:830–844
About this article
Cite this article
Watanabe, M., Tanaka, R. & Takeda, N. Magnetic resonance imaging and histopathology of cerebral gliomas. Neuroradiology 34, 463–469 (1992). https://doi.org/10.1007/BF00598951
- Cerebral glioma
- Magnetic resonance imaging