European Journal of Nuclear Medicine

, Volume 8, Issue 11, pp 509–511 | Cite as

Massive splenomegaly with multiple defects in a chronic myelogenous leukemia demonstrated by99mTc-sulfur colloid scintigraphy

  • Wei-Jen Shih
  • Frank H. DeLand
  • Peggy A. Domstad
Case Reports


A99mTc-sulfur colloid liver-spleen scintigram of a 78-year-old woman with a painful, large mass in the left upper quadrant of the abdomen revealed massive splenomegaly with multiple areas of absent radioactivity. Splenectomy was performed and the removed spleen, weighing 2,010 g, was confirmed to contain acute and old infarcts with leukemic cell and megakaryocyte infiltration.


Public Health Leukemia Nuclear Medicine Leukemic Cell Large Mass 
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  1. 1.
    Blank E, Champbell JR (1973) Epidermoid cysts of the spleen. Pediatrics 51:75–84Google Scholar
  2. 2.
    Davis CE, Montero JM, Van Horn CN (1973) Large splenic cysts. Ann Surg 173:686–692Google Scholar
  3. 3.
    Doolas A, Nolte M, McDonald OW, Economou SG (1978) Splenic cyst. J Surg Oncol 10:369–387Google Scholar
  4. 4.
    Fitzer PM (1976) 99mTC-pertechnetate angiography and sulfur colloid scans in epidermoid cyst of spleen. Clin Nucl Med 17:196–199Google Scholar
  5. 5.
    Garfunkel F (1976) Epidermoid cyst of the spleen. J Nucl Med 17:196–199Google Scholar
  6. 6.
    Garvey JW, Peyser I, Delany HM (1974) Traumatic cyst of the spleen. An unusual presentation. J Trauma 14:974–979Google Scholar
  7. 7.
    Gilmartin D (1978) Familial multiple epidermoid cyst of the spleen. Conn Med 42:297–300Google Scholar
  8. 8.
    McClure JN, Park YH (1975) Solitary metastic carcinoma of the spleen. South Med J 68:101–104Google Scholar
  9. 9.
    Novetsky GJ, Epstein AJ (1982) Cystic lymphangiomatosis. An unusual cause of splenic scintigraphic defects. Clin Nucl Med 7:416–417Google Scholar
  10. 10.
    Scully RE (ed) (1976) Casr records of massachusetts general hospital (weekly clinicopathological exercise) case 41: 1976. N Eng J Med 295:828—834Google Scholar
  11. 11.
    Spencer RP (1981) The spleen as a hematological organ. In: Freeman LM, Weissman HS (eds) Nuclear Medicine Annual, Raven Press, New York, pp 91–118Google Scholar
  12. 12.
    Shih W-J, Lloyd D, Reba RC, Martin S, Rankin D, Morelli L (1982) Giant epidermoid cyst of spleen. J FL M Assoc 69:387–390Google Scholar
  13. 13.
    Shih W-J, Sauerbrunn BJL, Bates HR (1982) Total non-visualization of the spleen on Tc-99m sulfur colloid and In-113m chloride blood pool images. Eur J Nucl Med 7:513–514Google Scholar
  14. 14.
    Wright FW, Williams EW (1974) Large post-traumatic splenic cyst diagnosed by radiology, isotope scintigraphy and ultrasound. Br J Radiol 47:454–456Google Scholar
  15. 15.
    Yam LT, Crosby WH (1979) Spontaneous rupture of spleen in leukemic reticuloendoliosis. Am J Surg 137:270–273Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Wei-Jen Shih
    • 1
    • 2
  • Frank H. DeLand
    • 1
    • 2
  • Peggy A. Domstad
    • 1
    • 2
  1. 1.University of Kentucky Medical CenterLexingtonUSA
  2. 2.Veterans Administration Medical CenterLexingtonUSA

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